| Yazarlar (13) |
Vildan Ozer
|
|
Ozgen Gonenc Cekic
|
|
Ozlem Bulbul
|
Doç. Dr. Davut AYDIN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Eser Bulut
|
|
Firdevs Aksoy
|
|
Mehtap Pehlivanlar Kucuk
|
|
Suleyman Caner Karahan
|
|
Ebru Emel Sozen
|
|
Esra Ozkaya
|
|
Polat Kosucu
|
|
Yunus Karaca
|
|
Suleyman Turedi
|
| Özet |
| Introduction:The workload of physicians increased due to the number of patients presenting withsuspicion of coronavirus 2019 (COVID-19) and the prolonged wait times in the emergency departmentduring the COVID-19 pandemic. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) is aprotein present in platelets and endothelial cells; it is activated by inflammation from COVID-19 and maybe associated with COVID-19's known thrombotic risk. We aimed to determine whether SCUBE-1 levelsare diagnostically correlated in suspected COVID-19 patients, and whether SCUBE-1 correlated withseverity of disease and, therefore, might be useful to guide hospitalization/discharge decisions. Methods:The suspected COVID-19 patients cared for at tertiary healthcare institutions for one yearbetween May 2021-May 2022 were examined in this study. The subjects were both suspected COVID-19 patients not ultimately found to have COVID-19 and those who were diagnosed with COVID-19. Bymodifying the disease severity scoring systems present in COVID-19 guidelines in 2021, the COVID-19-positive patient group was classified as mild, moderate, severe, and critical, and compared using theSCUBE-1 levels. Moreover, SCUBE-1 levels were compared between the COVID-19 positive group andthe COVID-19 negative group. Results:A total of 507 patients were considered for the present study. After excluding 175 patients forincomplete data and alternate comorbid organ failure. we report on 332 patients (65.5%). Of these 332patients, 80 (24.0%) were COVID-19 negative, and 252 (76.0%) were COVID-19 positive. Of 252 (100%)patients diagnosedwith COVID-19,74 (29.4%) were classified as mild, 95 (37.7%) moderate, 45 (17.8%)severe, and 38 (15.1%) critical. The SCUBE-1 levels were statistically different between COVID-19positive (8.48 +/- 7.42 nanograms per milliliter [ng/mL]) and COVID-19 negative (1.86 +/- 0.92 ng/mL)patients (P<0.001). In the COVID-19 positive group, SCUBE-1 levels increased with disease severity(mild=3.20 +/- 1.65 ng/mL, moderate=4.78 +/- 2.26 ng/mL, severe=13.68 +/- 3.95 ng/mL, and critical=21.87 +/- 5.39 ng/mL) (P<0.001). The initial SCUBE-1 levels of discharged patients were significantlylower than those requiring hospitalization (discharged=2.89 ng/mL [0.55-8.60 ng/mL]; ward admitted=7.13 ng/mL [1.38-21.29 ng/mL], and ICU admitted=21.19 ng/mL [10.58-37.86 ng/mL]) (P<0.001). Conclusion:The SCUBE-1 levels were found to be differentiated between patients with and withoutCOVID-19 and to be correlated with the severity of illness. [West J Emerg Med. 2024;25(6)975-984.] |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | WESTERN JOURNAL OF EMERGENCY MEDICINE |
| Dergi ISSN | 1936-900X Wos Dergi Scopus Dergi |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2024 |
| Cilt No | 25 |
| Sayı | 6 |
| Doi Numarası | 10.5811/westjem.18586 |
| Atıf Sayıları |
