Hsp Inhibitor is Affective Against Adenocarcinomic Human Alveolar Basal Epithelial Cells Through Modulating ERK/MAPK Signaling Pathway
Yazarlar (6)
Servet Tunoğlu
Istanbul Üniversitesi, Türkiye
Dr. Öğr. Üyesi Lütfi TUTAR
Kırşehir Ahi Evran Üniversitesi, Türkiye
Mehmet Gümüş
Yozgat Bozok Üniversitesi, Türkiye
Ezgi Nurdan Yenilmez Tunoğlu
Demiroglu Science University, Türkiye
İrfan Koca
Yozgat Bozok Üniversitesi, Türkiye
Yusuf Tutar
Recep Tayyip Erdoğan Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 21 / 2 / – | DOI | 10.1002/cbdv.202301422 |
| Makale Linki | https://doi.org/10.1002/cbdv.202301422 | ||
| Özet |
| The extracellular signal‐regulated kinase (ERK) ‐ mitogen‐activated protein kinase (MAPK) pathway regulates cell proliferation, differentiation, and apoptosis. Heat Shock Protein 90 (HSP90) is required to activate proto‐oncogenic protein kinases and promotes tumor growth through anti‐apoptotic effects on A549‐non‐small cell lung cancer (NSCLC). Therefore, deregulation of the ERK‐MAPK pathway and abnormal expression of HSP90 are reasonably frequent events in NSCLC. In this study, novel perimidine‐pyrazole compounds employed to block ERK‐MAPK deregulation through inhibiting HSP dependent cancer cell survival mechanisms. A set of perimidine‐pyrazole derivatives effects was monitored on NSCLC cell line. Array experiments performed to understand the effect of the compounds on signaling pathways and results were analyzed by gene enrichment analysis. Further, senescence and apoptosis … |
| Anahtar Kelimeler |
| Senescence | Apoptosis | Perimidine-pyrazole | NSCLC | A549 | HSP |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 5 |
| SCOPUS | 5 |
| Google Scholar | 5 |