Non-genetic heterogeneity and immune subtyping in breast cancer: Implications for immunotherapy and targeted therapeutics
Yazarlar (6)
Mudassir Hassan
Government College University Faisalabad, Pakistan
Dr. Öğr. Üyesi Lütfi TUTAR
Kırşehir Ahi Evran Üniversitesi, Türkiye
Duygu Sarı Ak
University Of Health Sciences, Türkiye
Azhar Rasul
Government College University Faisalabad, Pakistan
Ejaz Basheer
Government College University Faisalabad, Pakistan
Yusuf Tutar
Recep Tayyip Erdoğan Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Translational Oncology (Q2) | ||
| Dergi ISSN | 1936-5233 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2024 |
| Cilt / Sayı / Sayfa | 47 / 1 / 102055–102055 | DOI | 10.1016/j.tranon.2024.102055 |
| Makale Linki | https://doi.org/10.1016/j.tranon.2024.102055 | ||
| Özet |
| Breast cancer (BC) is a complex and multifactorial disease, driven by genetic alterations that promote tumor growth and progression. However, recent research has highlighted the importance of non-genetic factors in shaping cancer evolution and influencing therapeutic outcomes. Non-genetic heterogeneity refers to diverse subpopulations of cancer cells within breast tumors, exhibiting distinct phenotypic and functional properties. These subpopulations can arise through various mechanisms, including clonal evolution, genetic changes, epigenetic changes, and reversible phenotypic transitions. Although genetic and epigenetic changes are important points of the pathology of breast cancer yet, the immune system also plays a crucial role in its progression. In clinical management, histologic and molecular classification of BC are used. Immunological subtyping of BC has gained attention in recent years as compared … |
| Anahtar Kelimeler |
| Immune subtypes | Tumor immune microenvironment | Drug resistance | Non-genetic heterogeneity | Breast cancer |
Science Direct
Non-genetic heterogeneity and immune subtyping in breast cancer: Implications for immunotherapy and targeted therapeutics
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 5 |
| SCOPUS | 4 |
| Google Scholar | 7 |