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Non-genetic heterogeneity and immune subtyping in breast cancer: Implications for immunotherapy and targeted therapeutics   
Yazarlar (6)
Mudassir Hassan
Dr. Öğr. Üyesi Lütfi TUTAR Dr. Öğr. Üyesi Lütfi TUTAR
Kırşehir Ahi Evran Üniversitesi, Türkiye
Duygu Sarı Ak
Türkiye
Azhar Rasul
Ejaz Basheer
Yusuf Tutar
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Devamını Göster
Özet
Breast cancer (BC) is a complex and multifactorial disease, driven by genetic alterations that promote tumor growth and progression. However, recent research has highlighted the importance of non-genetic factors in shaping cancer evolution and influencing therapeutic outcomes. Non-genetic heterogeneity refers to diverse subpopulations of cancer cells within breast tumors, exhibiting distinct phenotypic and functional properties. These subpopulations can arise through various mechanisms, including clonal evolution, genetic changes, epigenetic changes, and reversible phenotypic transitions. Although genetic and epigenetic changes are important points of the pathology of breast cancer yet, the immune system also plays a crucial role in its progression. In clinical management, histologic and molecular classification of BC are used. Immunological subtyping of BC has gained attention in recent years as compared …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Translational Oncology
Dergi ISSN 1936-5233 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili Türkçe
Basım Tarihi 09-2024
Cilt No 47
Sayfalar 102055 / 102055
Doi Numarası 10.1016/j.tranon.2024.102055
Makale Linki https://doi.org/10.1016/j.tranon.2024.102055