Novel a-N-heterocyclic thiosemicarbazone complexes: synthesis, characterization, and antimicrobial of properties investigation
Yazarlar (5)
Düzce Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırklareli Üniversitesi, Türkiye
Kocaeli University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | RSC ADVANCES (Q2) | ||
| Dergi ISSN | 2046-2069 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2024 |
| Cilt / Sayı / Sayfa | 14 / 40 / 29308–29318 | DOI | 10.1039/d4ra04002c |
| Özet |
| In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria ( ATCC9341, ATCC12228, RSKK863) and Gram-negative bacteria ( ATCC27853, ATCC27853, ATCC51342, H NCTC9018394, NCTC2966, RSKK96026) and yeast ( Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cucomplexes showed stronger antifungal effects. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |