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Evaluation of probiotics’ efficiency on cariogenic bacteria: randomized controlled clinical study      
Yazarlar (6)
Didem Sakaryalı Uyar
Türkiye
Aylin Üsküdar Güçlü
Türkiye
Dr. Öğr. Üyesi Ekin ÇELİK Dr. Öğr. Üyesi Ekin ÇELİK
Kırşehir Ahi Evran Üniversitesi, Türkiye
Betül Memiş Özgül
Türkiye
Aylin Altay Koçak
Türkiye
Ahmet Celal Başustaoğlu
Türkiye
Devamını Göster
Özet
Probiotics are live beneficial bacteria to human health and their efficiency on oral health is still being investigated. The purpose of this study was to evaluate the level of Streptococcus mutans and Lactobacillus species with and without the use of probiotics for six-months after the treatment of all dental caries under general anesthesia. Fifty-eight pediatric patients without any systemic diseases, whose dental treatments were completed under general anesthesia (GA), were included in the study. The patients were recruited in two-groups; Group A: Patients started using probiotics after GA and Group B: Patients did not use probiotics after GA. Saliva samples were taken from all patients on the day before GA (T0), at one-month (T1), three-month (T2) and six-month (T3) follow-up after GA. The counts of cariogenic bacteria were determined by the analysis of saliva samples using real-time polymerase chain reaction. Statistical significance level was accepted as p < 0.05. There was statistically significant difference between Group A and B for T0, T1, T2 and T3 regarding S. mutans (p = 0.001, p = 0.04, p = 0.04, p = 0.03; p < 0.05). However, there was no statistically significant difference between groups regarding Lactobacillus species (p ≥ 0.05). Probiotic use and treatment of all caries significantly reduced the level of S. mutans but not Lactobacillus species. Furthermore, S. mutans decreased after cessation of probiotics, but it was not statistically significant. Study was registered as "Effects of Probiotics on Streptococcus mutans and Lactobacillus species" with the registration number of NCT05859646 (16/05/2023) at https://www. gov Protocol Registration and Results System.
Anahtar Kelimeler
Lactobacillus species | Oral flora | Probiotics | Streptococcus mutans | Dental caries
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı BMC Oral Health
Dergi ISSN 1472-6831 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 08-2024
Cilt No 24
Sayı 1
Doi Numarası 10.1186/s12903-024-04659-y
Makale Linki https://doi.org/10.1186/s12903-024-04659-y