| Yazarlar (7) |
Öğr. Gör. Ertuğrul DAĞLI
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mehtap NİSARI
ERCİYES ÜNİVERSİTESİ |
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Dilara PATAT
ANKARA MEDİPOL ÜNİVERSİTESİ |
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Dicle ÇAYAN
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ |
|
Emre ATAY
AFYONKARAHİSAR SAĞLIK BİLİMLERİ ÜNİVERSİTESİ |
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Tolga ERTEKİN
AFYONKARAHİSAR SAĞLIK BİLİMLERİ ÜNİVERSİTESİ |
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Sümeyye UÇAR
ERCİYES ÜNİVERSİTESİ |
| Özet |
| Objective: Folic acid (FA) is a key antioxidant with substantial metabolic roles, and research has demonstrated its effectiveness in reducing congenital anatomical development disorders. This study explores the impact of folic acid on embryo development under hypoxia-induced conditions in embryo cultures. Materials and Methods: Female Wistar albino rats, aged 4--10 months and weighing 150-- 250 grams, were utilized for this research. Embryos were extracted from the maternal womb on the 9.5th day of pregnancy. We established six groups, each consisting of 10 embryos: Control (C), Hypoxia (H), 1 mmol FA (1FA), 2 mmol FA (2FA), Hypoxia + 1 mmol FA (H1FA), and Hypoxia + 2 mmol FA (H2FA). Following a 48-hour culture period, the groups were assessed morphologically. Results: When comparing the morphological parameters of the Control and Hypoxia groups, it was statistically demonstrated that the Control group completed its development, whereas the Hypoxia group exhibited insufficient development (p<0.05). There were statistically significant differences between the Hypoxia group and the Hypoxia + 1 mmol FA and Hypoxia + 2 mmol FA groups (p<0.05). Both the Hypoxia + 1 mmol FA and Hypoxia + 2 mmol FA groups demonstrated better embryonic development compared to the Hypoxia group (p<0.05). Conclusion: The study has established that FA has positive effects on embryos exposed to hypoxic conditions, which result in developmental delays. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Journal of clinical practice and research |
| Dergi ISSN | 2980-2156 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2024 |
| Cilt No | 46 |
| Sayı | 3 |
| Sayfalar | 251 / 258 |
| Doi Numarası | 10.14744/cpr.2024.64375 |
| Atıf Sayıları |
