Quercetin: Potential antidiabetic effects through enzyme inhibition and starch digestibility
Yazarlar (7)
Deniz Günal Köroğlu
Türkiye
Gizem Çatalkaya
Türkiye
Büşra Yusufoğlu
İstanbul Teknik Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gizem KEZER
Kırşehir Ahi Evran Üniversitesi, Türkiye
Tuba Esatbeyoglu
A. M. Abd El-Aty
Esra Çapanoğlu Güven
Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Food Safety and Health | ||
| Dergi ISSN | 2835-1096 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2024 |
| Cilt / Sayı / Sayfa | 0 / 0 / – | DOI | 10.1002/fsh3.12066 |
| Makale Linki | http://dx.doi.org/10.1002/fsh3.12066 | ||
| Özet |
| Diabetes mellitus involves high blood sugar levels due to insufficient insulin action. Furthermore, enzymes such as α‐amylase and α‐glucosidase break down carbohydrates into glucose, leading to postprandial hyperglycemia. Flavonoids, particularly quercetin, inhibit these enzymes, slowing carbohydrate digestion and reducing glucose absorption. Quercetin has significant hypoglycemic effects with inhibitory concentration (IC50) values comparable to acarbose, a standard inhibitor, suggesting its potential as a natural alternative for diabetes management. In silico models, including molecular docking, molecular dynamics (MD) simulations, and quantitative structure‐activity relationship (QSAR) approaches, help researchers understand the molecular interactions of therapeutic agents. These techniques identify potential inhibitors, determine enzyme‐inhibitor structures, and calculate binding energies, correlating … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 21 |