| Yazarlar (5) |
Mehmet Mürşit Temüz
Türkiye |
|
Nevin Çankaya
Türkiye |
|
Safiye Elif Korcan
Türkiye |
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Tuğba Kahraman
|
| Özet |
| The antibacterial, antifungal, and antioxidant activities of 2-chloro--(4-methoxyphenyl)acetamide (-acetamide) and 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA) were investigated by experiments and analyses. MPAEMA has an antibacterial effect only against Gram-positive . It was determined that this did not affect any other bacteria and yeast. On the other hand, -acetamide showed antimicrobial activity against ATCC 25923, ATCC 90030, NRRL 744, ATCC 551289, ATCC 25922, NRLLB4420, ATCC 27853, and ATCC 1911. -Acetamide showed the greatest antifungal effect by inhibiting the colony growth of (98%). This was followed by with 83% and with 21%. MPAEMA inhibited colony growth of by 95% and that of by 91%. Also, -acetamide and MPAEMA had a scavenging effect on free radicals. According to results of the analysis, the antimicrobial effect of these compounds is due to their effect on DNA ligase. Based on drug-likeness analysis, they were found to be consistent with the Lipinski, Veber, or Ghose rule. -Acetamide and MPAEMA may be used as drugs. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ACS Omega |
| Dergi ISSN | 2470-1343 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 02-2024 |
| Cilt No | 9 |
| Sayı | 7 |
| Sayfalar | 7910 / 7922 |
| Doi Numarası | 10.1021/acsomega.3c07836 |
| Makale Linki | http://dx.doi.org/10.1021/acsomega.3c07836 |
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 1 |
