First In Vitro–In Silico Analysis for the Determination of Antimicrobial and Antioxidant Properties of 2-(4-Methoxyphenylamino)-2-oxoethyl Methacrylate and p-Acetamide
Yazarlar (5)
Firat University, Türkiye
Usak University, Türkiye
Usak University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Ege University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | ACS OMEGA (Q2) | ||
| Dergi ISSN | 2470-1343 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2024 |
| Cilt / Sayı / Sayfa | 9 / 7 / 7910–7922 | DOI | 10.1021/acsomega.3c07836 |
| Makale Linki | http://dx.doi.org/10.1021/acsomega.3c07836 | ||
| Özet |
| The antibacterial, antifungal, and antioxidant activities of 2-chloro--(4-methoxyphenyl)acetamide (-acetamide) and 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA) were investigated by experiments and analyses. MPAEMA has an antibacterial effect only against Gram-positive . It was determined that this did not affect any other bacteria and yeast. On the other hand, -acetamide showed antimicrobial activity against ATCC 25923, ATCC 90030, NRRL 744, ATCC 551289, ATCC 25922, NRLLB4420, ATCC 27853, and ATCC 1911. -Acetamide showed the greatest antifungal effect by inhibiting the colony growth of (98%). This was followed by with 83% and with 21%. MPAEMA inhibited colony growth of by 95% and that of by 91%. Also, -acetamide and MPAEMA had a scavenging effect on free radicals. According to results of the analysis, the antimicrobial effect of these compounds is due to their effect on DNA ligase. Based on drug-likeness analysis, they were found to be consistent with the Lipinski, Veber, or Ghose rule. -Acetamide and MPAEMA may be used as drugs. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| WoS | 3 |
| Google Scholar | 4 |