| Yazarlar (5) |
Dilek NARTOP
Düzce Üniversitesi, Türkiye |
|
Elvan Hasanoğlu ÖZKAN
Gazi Üniversitesi, Türkiye |
Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Nurdan Kurnaz YETİM
Kırklareli Üniversitesi, Türkiye |
|
İnci ÖZDEMİR
Kocaeli Üniversitesi, Türkiye |
| Özet |
| In this paper, eight novel alpha-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the alpha-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects. In this paper, eight novel alpha-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via1H-NMR, IR, TGA, UV-Vis, molar conductance and magnetic susceptibility measurements. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | RSC Advances |
| Dergi ISSN | 2046-2069 |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2024 |
| Cilt No | 14 |
| Sayı | 40 |
| Sayfalar | 293088 / 29318 |
| Doi Numarası | 10.1039/d4ra04002c |
| Atıf Sayıları | |
| WoS | 1 |
