| Yazarlar |
Abdullah Demirbaş
Türkiye |
|
Gözde Ulutaş Demirbaş
Türkiye |
|
Koray Durmaz
Lokman Hekim Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Zuhal METİN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Scabies is a prevalent ectoparasitic infectious disease, caused by the mite Sarcoptes scabiei. As a consequence of the infestation, localised cutaneous inflammation, pruritus and polymorphic skin lesions develop. The primary symptoms of scabies manifest as hypersensitivity-like reactions and immune responses, the precise mechanisms of which remain poorly defined. The objective of this study was to evaluate the effects of oral ivermectin treatment in patients with scabies on the systemic immune response and the patient's quality of life (QoL). Patients admitted to the dermatology outpatient clinic and diagnosed with scabies were administered oral ivermectin treatment following diagnosis at week 0 and 2. Laboratory tests were conducted to measure complete blood count (CBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels before treatment and at week 4. The systemic immune-inflammation index (SII) was calculated using the platelet, neutrophil and lymphocyte counts. Additionally, data pertaining to the Dermatological Life Quality Index (DLQI) were recorded. In 119 patients (51 males) diagnosed with scabies, increases in ESR, CRP, and SII values and decreases in inflammatory cell counts and DLQI scores were observed one month after treatment with oral ivermectin. The results of the study showed that the use of oral ivermectin, a scabicidal agent, triggered the inflammatory response and improved the QoL of the patients. |
| Anahtar Kelimeler |
| Scabies | Systemic inflammation | Life quality | Antiscabies treatment |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ARCHIVES OF DERMATOLOGICAL RESEARCH |
| Dergi ISSN | 0340-3696 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2024 |
| Cilt No | 316 |
| Sayı | 8 |
| Sayfalar | 1 / 5 |
| Doi Numarası | 10.1007/s00403-024-03341-1 |
| Makale Linki | http://dx.doi.org/10.1007/s00403-024-03341-1 |
| Atıf Sayıları |
