| Yazarlar (5) |
Prof. Dr. Harun ÇİFTÇİ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Çiğdem ER ÇALIŞKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Burcu Yazıcı
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Akın Tekcan
Amasya Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kübra ÖZTÜRK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| In recent years, the use of nanoparficles has gained significant attenfion in cancer research due to their unique properfies and potenfial as targeted drug delivery systems. This study focuses on the synthesis and characterizafion of Primula vulgaris stabilized silver nanoparficles (PVAgNPs) and the evaluafion of in vitro cytotoxicity against MCF-7 cells. In this study, PVAgNPs were synthesized separately from the flower (PVAgNPsF), leaf (PVAgNPsL), and root (PVAgNPsR) extracts of Primula vulgaris (PV). The PVAgNPs were characterized by various analyfical techniques, including UV-Visible absorpfion spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffracfion, dynamic light scattering (DLS), zeta potenfial, and scanning electron microscopy (SEM). The maximum absorpfion wavelengths are obtained at 437 nm for the PVAgNPsR samples and at 440 nm for the PVAgNPsF and PVAgNPsL samples. Based on the XRD spectra, PVAgNPs were found to have a cubic crystal structure. On average, the zeta potenfial values of PVAgNPs ranged from-14 to-28 mV, indicafing that they were quite stable. SEM analysis showed that the synthesized PVAgNPs were predominantly spherical in shape and ranged in size from 40 to 89 nm. The iCELLigence Real-Time Cell Analysis (RTCA) system was used to evaluate the efficacy of the synthesized PVAgNPs against MCF-7 cell lines. After 24 h of incubafion, the inhibitory concentrafions (IC50) of PVAgNPsL PVAgNPsR, and PVAgNPsF were determined to be 30.37, 36.74, and 57.64 µg/mL, respecfively, indicafing that PVAgNPs have an in vitro cytotoxic effect on MCF-7 cells. In conclusion, the … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Iranian Journal of Chemistry and Chemical Engineering (IJCCE) |
| Dergi ISSN | 1021-9986 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2024 |
| Cilt No | 43 |
| Sayı | 7 |
| Sayfalar | 2556 / 2571 |
| Doi Numarası | 10.30492/ijcce.2024.2001893.6020 |
| Makale Linki | https://www.ijcce.ac.ir/index.php/article_711478_ed69ddf83a0e37a2cf6af318404e39a0.pdf |
| Atıf Sayıları | |
| Google Scholar | 2 |
