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Synthesis and in vitro antimicrobial evaluation of novel potent bioactive heterocyclic compounds.  
Yazarlar (4)
Ahsen Zeynep Macit
Düzce Üniversitesi, Türkiye
Elvan Hasanoğlu Özkan
Gazi Üniversitesi, Türkiye
Prof. Dr. Hatice ÖĞÜTCÜ Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Dilek NARTOP
Düzce Üniversitesi, Türkiye
Devamını Göster
Özet
In the present work, the antibacterial and antifungal properties of six new heterocyclic Schiff bases (HSb1, HSb2, HSb3, HSb4, HSb5, HSb6) were evaluated as potential bioactive compounds against the disease-causing pathogenic microorganisms (S.epidermidis, S.aureus, B.cereus RSKK863, E.aerogenes, P.aeroginosa sp., K. pneumonia, S. type H, P.vulgaris, E. coli and (C.albicans Y-1200-NIH). The well-diffusion-method was used to determine the antimicrobial activity. For this purpose, heterocyclic Schiff bases were synthesized by condensation reaction of aldehyde derivatives and thiosemicarbazide derivatives. Spectral analysis techniques (organic elemental analysis, FT-IR,H-1-NMR, HRMS, SEM-EDX) were used to characterize the synthesized compounds. It was determined that all the newly synthesized heterocyclic Schiff bases exhibited sound, high or moderate inhibitory effects on the growth of selected different standard antibiotics. [Graphical Abstract]
Anahtar Kelimeler
heterocyclic compounds | schiff bases | biological activity | pathogenic strains | thiazole
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Polycyclic Aromatic Compounds
Dergi ISSN 1026-7743
Dergi Tarandığı Indeksler
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 06-2024
Cilt No 440
Sayı 1
Sayfalar 6862 / 6873
Doi Numarası 10.1080/10406638.2023.2298863