| Yazarlar |
İdris Türel
Adıyaman Üniversitesi, Türkiye |
|
Hanefi Özbek
İstanbul Medipol Üniversitesi, Türkiye |
|
Remzi Erten
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Ahmet Cihat Öner
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Prof. Dr. Nureddin CENGİZ
Sakarya Üniversitesi, Türkiye |
|
Orhan Yılmaz
Yüzüncü Yıl Üniversitesi, Türkiye |
| Özet |
| Objective: The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM). Materials and Methods: Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective Activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed. Results: Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups. Conclusion: The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities. |
| Anahtar Kelimeler |
| Anti-inflammatory activity | hepatoprotective activity | Plantago major L. | rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INDIAN JOURNAL OF PHARMACOLOGY |
| Dergi ISSN | 0253-7613 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2009 |
| Cilt No | 41 |
| Sayı | 3 |
| Sayfalar | 120 / 124 |
| Doi Numarası | 10.4103/0253-7613.55211 |
| Atıf Sayıları | |
| WoS | 44 |
