| Yazarlar |
Prof. Dr. Nureddin CENGİZ
Sakarya Üniversitesi, Türkiye |
|
Servet Kavak
Muğla Sıtkı Koçman Üniversitesi, Türkiye |
|
A Güzel
|
|
Hanefi Özbek
İstanbul Medipol Üniversitesi, Türkiye |
|
Hava Bektaş
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Aydın Him
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Ender Erdoğan
Selçuk Üniversitesi, Türkiye |
|
R Balaharoğlu
|
| Özet |
| More than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl4). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl4-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl4. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl4 group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from the CCl4 group. Sesame did not show a hepatoprotective effect in CCl4-induced liver toxicity. |
| Anahtar Kelimeler |
| Carbon tetrachloride | Histology | Liver | Rat | Sesame | Sesamum indicum L. | ALT | AST | ALP |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF MEMBRANE BIOLOGY |
| Dergi ISSN | 0022-2631 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Cilt No | 246 |
| Sayı | 1 |
| Sayfalar | 1 / 6 |
| Doi Numarası | 10.1007/s00232-012-9494-7 |
| Makale Linki | http://www.ncbi.nlm.nih.gov/pubmed/22915054 |
| Atıf Sayıları | |
| WoS | 18 |
