| Yazarlar |
Mehmet Tütüncü
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Hanefi Özbek
İstanbul Medipol Üniversitesi, Türkiye |
|
Mehmet Karaca
Mehmet Akif Ersoy Üniversitesi, Türkiye |
|
Hasan Altan Akkan
Mehmet Akif Ersoy Üniversitesi, Türkiye |
|
İrfan Bayram
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Prof. Dr. Nureddin CENGİZ
Sakarya Üniversitesi, Türkiye |
|
F Özgökçe
|
|
Aydın Him
Ondokuz Mayıs Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to investigate the effects of the diethylether extract of Helichrysum plicatum DC. subsp. plicatum (HP) and Tanacetum balsamita L. subsp. balsamitoides (Sch. Bip.) Grierson (Asteraceae) (TB) in carbontetrachloride (CCl(4))-induced acute liver toxicity in rats. Acute liver toxicity was induced by injecting CCl(4) (0.8 mL kg(-1)) intraperitoneally for 7 days. The control group received isotonic saline only. The reference group received 50 mg kg(-1) silibinin. TB and HP extract was injected in doses of 25, 50 and 100 mg kg(-1). Body weights were measured daily during the experiment. On the 8th day of the experiments blood and liver samples were collected. Serum Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were measured in serum samples. Tissue samples were evaluated histopathologically. Some of the rats in TB and HP groups died during the experiments. Serum ALT levels were higher in the TB and HP groups than those in the CCl(4) group. Histopathological findings were similar in the CCl(4), TB and HP groups. The body weight loss was more in the TB and HP groups compared to that of the CCl(4) group. It is concluded that the diethylether extract of Helichrysum plicatum DC. subsp. plicatum and Tanacetum balsamita L. subsp. balsamitoides (Sch. Bip.) Grierson (Asteraceae) did not have a protective effect in carbontetrachloride (CCl(4))-induced acute liver toxicity in rats and even exacerbated the toxicity. |
| Anahtar Kelimeler |
| Tanacetum balsamita L. subsp balsamitoides (Sch Bip.) Grierson | Helichrysum plicatum DC. subsp Plicatum | Asteraceae | hepatoprotective effect | rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES |
| Dergi ISSN | 1683-9919 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2010 |
| Cilt No | 5 |
| Sayı | 7 |
| Sayfalar | 465 / 471 |
