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Glutamate responsiveness of medial vestibular nucleus neurons in aged rats    
Yazarlar
A Him
R Guneser
Prof. Dr. Nureddin CENGİZ Prof. Dr. Nureddin CENGİZ
Sakarya Üniversitesi, Türkiye
G Oztürk
Özet
Disequilibrium, dizziness, vertigo and falls are vestibular system-related problems which are very common especially in older people. In order to clarify these age-related disorders one must understand first the age-related changes in the properties of vestibular neurons that are responsible for equilibrium. The responsiveness of medial vestibular nucleus (MVN) neurons to the NMDA and AMPA/kainate receptor agonists was investigated in slices prepared from young and aged rats using extracellular single cell recording techniques. In both young and aged rats bath application of NMDA and AMPA caused a reversible, dose dependant increase in the spontaneous discharge of the MVN neurons. The excitatory effects of both NMDA and AMPA on the spontaneous activity of aged MVN neurons were similar to those of young MVN neurons. The spontaneous firing rates of the MVN cells were also similar in young and aged rats. These results suggest that the responsiveness of the NMDA and AMPA/kainate receptors and the excitability of the MVN neurons do not change with age. (C) 2009 Elsevier Inc. All rights reserved.
Anahtar Kelimeler
Aging | Medial vestibular nucleus | NMDA receptors | AMPA-kainate receptors
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı BRAIN RESEARCH BULLETIN
Dergi ISSN 0361-9230
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 01-2010
Cilt No 81
Sayı 1
Sayfalar 81 / 84
Doi Numarası 10.1016/j.brainresbull.2009.07.008
Makale Linki http://linkinghub.elsevier.com/retrieve/pii/S0361923009002160
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 7
Glutamate responsiveness of medial vestibular nucleus neurons in aged rats

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