| Yazarlar |
Engin Şahna
Fırat Üniversitesi, Türkiye |
|
Z Kurcer
|
|
F Ozturk
|
|
Prof. Dr. Nureddin CENGİZ
Sakarya Üniversitesi, Türkiye |
|
N Vardı
|
|
M Bırıncıoglu
|
|
E Olmez
|
| Özet |
| The effects of chronic oral administration of ethanol (7.2% daily during 24 weeks) on the contractions induced by phenylephrine (Phe) and the endothelium-dependent relaxation responses to acetylcholine (ACh) were studied in rat thoracic aorta. Ethanol pretreatment significantly attenuated the contractile responses to Phe, resulting in parallel shift of the concentration-response curve to the right. EC50 values of Phe were 64.6 +/- 11.2 and 95.5 +/- 8.5 nmol l(-1) in control and ethanol-fed rats, respectively. On the other hand, either calcium-induced contractions or relaxation responses to ACh and sodium nitroprusside were similar in the vessels of the control and ethanol-treated rats. These results suggest that chronic ethanol ingestion significantly attenuates the alpha(1)-adrenergic-induced contractions but does not affect the relaxation responses mediated by nitric oxide in rat aortic rings. (C) 2000 Academic Press. |
| Anahtar Kelimeler |
| ethanol | alpha-adrenergic | nitric oxide | rat aorta |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | PHARMACOLOGICAL RESEARCH |
| Dergi ISSN | 1043-6618 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2000 |
| Cilt No | 41 |
| Sayı | 6 |
| Sayfalar | 629 / 633 |
| Doi Numarası | 10.1006/phrs.1999.0629 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1043661899906291 |
| Atıf Sayıları | |
| WoS | 15 |
