Active shrinkage protects neurons following axonal transection
Yazarlar (12)
Türkiye
İstanbul Medipol Üniversitesi, Türkiye
Türkiye
Türkiye
Türkiye
Türkiye
Türkiye
Prof. Dr. Nureddin CENGİZ
Bandırma Onyedi Eylül Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
Bolu Abant İzzet Baysal Üniversitesi, Türkiye
İstanbul Medipol Üniversitesi, Türkiye
İstanbul Medipol Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | iScience |
| Dergi ISSN | 2589-0042 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2023 |
| Cilt No | 26 |
| Sayı | 10 |
| DOI Numarası | 10.1016/j.isci.2023.107715 |
| Makale Linki | http://dx.doi.org/10.1016/j.isci.2023.107715 |
| Özet |
| Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due to swelling and subsequent death. Using and neurotrauma model systems based on laser transection and surgical nerve cut, we demonstrated that axotomy triggers actomyosin contraction coupled with calpain activity. As a consequence, neurons shrink acutely to force water out through aquaporin channels preventing swelling and bursting. Inhibiting shrinkage increased the probability of neuronal cell death by about 3-fold. These studies reveal a previously unrecognized cytoprotective response mechanism to neurotrauma and offer a fresh perspective on pathophysiological processes in the nervous system. |
| Anahtar Kelimeler |
| Biological sciences | Neuroscience | Physiology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 7 |