Therapeutic effects of statins on chromosomal DNA damage of dyslipidemic patients
Yazarlar (6)
Türkiye
Erciyes University, Türkiye
Dr. Öğr. Üyesi Ayşe Nur COŞKUN DEMİRKALP
Kırşehir Ahi Evran Üniversitesi, Türkiye
University of Health Sciences Turkey, Türkiye
Kayseri Training & Research Hospital, Türkiye
Johns Hopkins University
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | EXPERIMENTAL BIOLOGY AND MEDICINE (Q2) | ||
| Dergi ISSN | 1535-3702 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2019 |
| Cilt / Sayı / Sayfa | 244 / 13 / 1089–1095 | DOI | 10.1177/1535370219871895 |
| Makale Linki | https://journals.sagepub.com/doi/abs/10.1177/1535370219871895 | ||
| Özet |
| Statins are a group of cholesterol lowering drugs and frequently used in the therapy of dyslipidemia. Our knowledge of the impact of statin therapy on DNA damage is as yet rudimentary. In this study, we aimed to assess the possible (1) genotoxic, cytostatic, and cytotoxic effects of statins in peripheral blood lymphocytes by using the cytokinesis-block micronucleus cytome (CBMN-cyt) assay, and (2) oxidative DNA damage by measuring plasma 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in response to statin therapy. Thirty patients with dyslipidemia who had no chronic diseases and did not use any medicines that interfere lipid values and twenty control subjects were included in the study. Statin therapy was initiated at risk-stratified doses. Blood samples were taken before and after treatment with statins and from control subjects, and CBMN-cyt assay parameters and 8-OHdG levels were evaluated. The … |
| Anahtar Kelimeler |
| Dyslipidemia | DNA damage | cytokinesis-block micronucleus cytome assay | micronucleus | statin therapy | 8-hydroxy-2 '-deoxyguanosine levels |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 12 |
| Google Scholar | 18 |