ISOLATION, ANTIFUNGAL ACTIVITY, AND MOLECULAR DOCKING ANALYSIS OF AXILLARIN FROM Tanacetum alyssifolium
Yazarlar (5)
Dr. Öğr. Üyesi Samed Şimşek Erzincan Binali Yıldırım Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yusuf BAYAR Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Hüseyin Akşit Erzincan Binali Yıldırım Üniversitesi, Türkiye
Ekrem Köksal Erzincan Binali Yıldırım Üniversitesi, Türkiye
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Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Environmental Engineering and Management Journal (Q4) | ||
| Dergi ISSN | 1582-9596 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 24 / 5 / 1035–1041 | DOI | 10.30638/eemj.2025.079 |
| Makale Linki | https://doi.org/10.30638/eemj.2025.079 | ||
| UAK Araştırma Alanları |
Fitopatoloji
Herboloji
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| Özet |
| The antifungal activity of axillarin, a polymethoxylated flavone isolated from the methanol extract of Tanacetum alyssifolium, was evaluated in vitro against several plant pathogenic fungi: Fusarium oxysporum f. sp. radicis-lycopersici (FORL), Alternaria alternata (AA), Fusarium oxysporum f. sp. niveum (FON), Phytophthora infestans, and Cylindrocarpon spp. Antifungal efficacy was assessed at concentrations of 200 and 400 g/mL using the agar Petri dish method. Axillarin inhibited fungal mycelial growth in a dose-dependent manner, with the highest inhibition observed for A. alternata (33.31%), followed by FORL (29.46%), Cylindrocarpon spp.(26.64%), and FON (18.21%). No inhibitory effect was detected against P. infestans. To support the experimental findings, molecular modeling was performed using GaussView 5.0 and GAUSSIAN 09 to determine the optimized 3D conformation of axillarin through potential … |
| Anahtar Kelimeler |
| antifungal activity | axillarin | molecular docking | plant pathogens | Tanacetum alyssifolium |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |