| Yazarlar |
Prof. Dr. Mustafa Kasım KARAHOCAGİL
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Aim Investigation of whether alternative intradermal (ID) and subcutaneous (SC) vaccination methods, which may be applied with low doses lowering the costs respectively in the rates of 1/10 and 1/4 when compared with classical IM 20 µg. hepatitis B vaccination method, provide or not sufficient protective antibody titers. Method 597 subjects consisting of hospital staff, students and risk groups, in whom measurement of antibody titers after 3 doses of vaccine was available, were enrolled in the study, and 483 subjects, in whom measurement of antibody titers after 4 doses of vaccine was achieved, fullfilled the study. Recombinant hepatitis B vaccine (Euvax B) was applied at 0, 1, 2 and 12 months intervals to IM group with standard 20 µg dose, to ID group with 2 µg dose and to SC group with 5 µg dose. Antibody measurements were done at 3rd and 13th months. Results While seroprotection rates were respectively 96.6%, 91.9% and 88.2% in IM, ID and SC groups at the 3rd month; they were 98.8%, 95.6% and 92.5% at the 13th month.. While the safest application route in view of side effects appears to be SC route, the most frequent local side effect was seen in ID group and the most frequent systemic side effect in IM group. None of these side effects leaded to interrupting the vaccination. Conclusion While ID hepatitis B vaccination appears to be an efficient method lowering the cost of vaccination in a rate of 9/10, alternative to classical IM vaccine application route; SC hepatitis B vaccine application route appears to be an efficient method lowering the cost vaccination in a rate of 3/4 according to IM vaccine application route, because of its ease of ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayımlanan tam makale |
| Dergi Adı | Van Tıp Derg |
| Dergi Tarandığı Indeksler | |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2006 |
| Cilt No | 13 |
| Sayı | 2 |
| Sayfalar | 28 / 35 |
