Spectral Characterization, Antioxidant, Antibacterial Activity, and Molecular Dynamics Simulation of a New Bis-benzimidazole Molecule, 1,5-Bis(1H-benzimidazol-2-yl)pentan-3-one
Yazarlar (5)
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
A. Tavman
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
O. Şahin
Sinop Üniversitesi, Türkiye
Sinop Üniversitesi, Türkiye
D. N. Çolak
Giresun Üniversitesi, Türkiye
Giresun Üniversitesi, Türkiye
A. A. Karaçelik
Giresun Üniversitesi, Türkiye
Giresun Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Russian Journal of Bioorganic Chemistry (Q3) | ||
| Dergi ISSN | 1068-1620 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 08-2024 |
| Cilt / Sayı / Sayfa | 50 / 4 / 1491–1511 | DOI | 10.1134/S1068162024040253 |
| Makale Linki | https://doi.org/10.1134/s1068162024040253 | ||
| Özet |
| Objective Bis-benzimidazoles are an interesting class of compounds due to their chelating characteristics, various biological effects, and fluorescence properties. Methods In this research, a new symmetric bis-benzimidazole derivative including a ketone group, 1,5-bis(1H-benzimidazol-2-yl)pentan-3-one (PBB), was synthesized and characterized. Antibacterial activity of PBB was tested against Gram-negative and Gram-positive bacteria. The total antioxidant capacity (as TEAC value) and free radical scavenging activity of (PBB) was determined by ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. Molecular modeling methods have been conducted in order to study the relationship between electronic characteristics and antioxidant activity. Results and Discussion Molecular modelling techniques and approaches were used to ensure that (PBB) synthesized in this study … |
| Anahtar Kelimeler |
| antioxidant activity | bis-benzimidazole | computational study | molecular modelling | X-ray crystal |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |
| Scopus | 1 |
| Web of Science | 1 |