Eco-friendly synthesis of new thiophene-based Schiff bases containing piperidine rings
   
Yazarlar (2)
Doç. Dr. Sertan AYTAÇ Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Özlem GÜNDOĞDU AYTAÇ Kırşehir Ahi Evran Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (ESCI dergilerinde yayınlanan tam makale)
Dergi Adı ORGANIC COMMUNICATIONS
Dergi ISSN 1307-6175 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler ESCI
Makale Dili Türkçe Basım Tarihi 04-2024
Cilt / Sayı / Sayfa 17 / 2 / 128–132 DOI 10.25135/acg.oc.170.24.06.3246
Makale Linki http://dx.doi.org/10.25135/acg.oc.170.24.06.3246
Özet
It is known that compounds containing sulfur in their structure have a wide range of biological activities, such as antibacterial, antiallergic, antimicrobial, anticancer, and anticonvulsant. In addition, nitrogen-containing heterocyclic compounds are also found in nature and the structure of drugs. Various compounds, such as piperidine and its derivatives, are also widely used in the synthesis of many drugs. Various Schiff bases have been synthesized in drug development studies, and they have been used in clinical applications as drugs and drug candidates. In this context, the synthesis of new thiophene-based Schiff bases containing piperidine rings is aimed. Green chemistry objectives were adhered to in the syntheses. Thiophene-2-carbaldehyde and piperidine derivatives were used as starting compounds, and new compounds containing thiophene-based piperidine were synthesized without adding any catalyst or solvent to the reaction medium. The desired Schiff base compounds were successfully synthesized in high yield and in a short time.
Anahtar Kelimeler
Schiff base | thiophene | piperidine | biological activity | microwave | green chemistry