| Yazarlar |
Figen Kır Şahin
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Serap Baydur Şahin
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Ülkü Mete Ural
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Medine Cumhur Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Şenol Şentürk
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Yeşim Bayoğlu Tekin
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Gülşah Balık
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Erkan Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Süleyman Yüce
|
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
| Özet |
| Obesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR). This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram. The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone. Elevated N1 and decreased VD levels may be related to the presence of high-normal BP or hypertension in PCOS subjects. N1 level may be associated with an increased BP due to its relation to inflammation and IR. |
| Anahtar Kelimeler |
| Nesfatin-1, vitamin D, polycystic ovary syndrome, insulin resistance, blood pressure, heart rate |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
