| Yazarlar (6) |
Yeşim Bayoğlu Tekin
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Süleyman Güven
Karadeniz Teknik Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Levent Tümkaya
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Emine Seda Güvendağ Güven
Karadeniz Teknik Üniversitesi, Türkiye |
| Özet |
| Objective: Resveratrol, a phytoalexin polyphenol, has anti-angiogenic, antioxidant, anti-inflammatory properties. We aimed to compare the anti-inflammatory and anti-angiogenic effects of resveratrol and leuprolide acetate (LA) in an experimental endometriosis model. Study design: A prospective experimental study was conducted in a University Surgical Research Center. Thirty-three non-pregnant female Sprague-Dawley rats, in which experimental model of endometriosis were surgically induced were randomly divided into four groups. Group 1 was administered 30 mg/kg resveratrol i.m. for 14 days, group 2 was given 1 mg/kg s.c. single dose LA, group 3 was administered both resveratrol and LA, and group 4 had no medication. After two weeks medication rats were sacrificed and size, histopathology and immunreactivity to matrix metalloproteinase (mmp)2, mmp9, vascular endothelial growth factor (VEGF) of the endometriotic implants were evaluated. Plasma and peritoneal fluid levels of interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) were analyzed. Results: The endometriotic implant volumes, histopathological grade and immunreactivity to mmp2, mmp9 and VEGF were significantly reduced (p < 0.001), and plasma and peritoneal fluid levels of IL-6, IL-8 and TNF-alpha were significantly decreased in group 1 and group 2 in comparison to group 3 and group 4 (p < 0.001). Conclusion: Resveratrol alone is a potential agent for the treatment of endometriosis and may be an alternative to LA. In contrast, the combination of LA and resveratrol decreased the anti-inflammatory and anti-angiogenic effects of each agent. Since resveratrol is widely used as an alternative therapy for a variety of conditions, it can undermine the effectiveness of LA. Therefore, caution should be exercised when used in combination with other agents. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
| Anahtar Kelimeler |
| Endometriosis | Rat model | Resveratrol | Leuprolide acetate | Treatment |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY |
| Dergi ISSN | 0301-2115 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 184 |
| Sayfalar | 1 / 6 |
| Doi Numarası | 10.1016/j.ejogrb.2014.10.041 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S030121151400565X |
| Atıf Sayıları | |
| WoS | 37 |
| Google Scholar | 59 |
