Protective effects of erdosteine vitamin E and vitamin C on renal injury induced by the ischemia reperfusion of the hind limbs in rats
Yazarlar (9)
Rana Sırmalı T.C. Sağlık Bakanlığı, Türkiye
Abdullah Armağan Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Faruk Öktem Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Efkan Uz Süleyman Demirel Üniversitesi, Türkiye
Prof. Dr. Aynur KIRBAŞ Recep Tayyip Erdoğan Üniversitesi, Türkiye
Soner Dönmez Nevşehir Haci Bektaş Veli Üniversitesi, Türkiye
Hacı Ramazan Yılmaz Mevlana Üniversitesi, Türkiye
Mesrur Selçuk Sılay Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Mehmet Sırmalı İstanbul Medeniyet Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turkish Journal of Medical Sciences | ||
| Dergi ISSN | 1300-0144 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 45 / 1 / 33–37 | DOI | 10.3906/sag-1310-38 |
| Makale Linki | https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=2880&context=medical | ||
| Özet |
| Background/aim: To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II (P < 0.01). Additionally, SOD, CAT, and GSH-Px activities were considerably (P < 0.05) decreased in group II. While CAT and GSH-Px activities were restored (P < 0.01) by vitamin E and C treatment, SOD activity was not significantly affected. While GSH-Px activities were higher (P < 0.05) with erdosteine administration, SOD and CAT activities were unchanged. Conclusion: The protective effect of vitamins C and E is higher than that of erdosteine treatment in reducing the oxidative stress after renal ischemia in this animal model. |
| Anahtar Kelimeler |
| Erdosteine | vitamin E | vitamin C | ischemia-reperfusion | antioxidant enzymes | oxidative stress | kidney |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 19 |
| SCOPUS | 20 |
| TRDizin | 2 |
| Google Scholar | 24 |