| Yazarlar |
Rana Sırmalı
|
|
Abdullah Armağan
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Faruk Öktem
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Efkan Uz
Süleyman Demirel Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Soner Dönmez
|
|
Hacı Ramazan Yılmaz
Mevlana Üniversitesi, Türkiye |
|
Mesrur Selçuk Sılay
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Mehmet Sırmalı
İstanbul Medeniyet Üniversitesi, Türkiye |
| Özet |
| Background/aim: To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II (P < 0.01). Additionally, SOD, CAT, and GSH-Px activities were considerably (P < 0.05) decreased in group II. While CAT and GSH-Px activities were restored (P < 0.01) by vitamin E and C treatment, SOD activity was not significantly affected. While GSH-Px activities were higher (P < 0.05) with erdosteine administration, SOD and CAT activities were unchanged. Conclusion: The protective effect of vitamins C and E is higher than that of erdosteine treatment in reducing the oxidative stress after renal ischemia in this animal model. |
| Anahtar Kelimeler |
| Erdosteine, vitamin E, vitamin C, ischemia-reperfusion, antioxidant enzymes, oxidative stress, kidney |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF MEDICAL SCIENCES |
| Dergi ISSN | 1300-0144 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 45 |
| Sayı | 1 |
| Sayfalar | 33 / 37 |
| Doi Numarası | 10.3906/sag-1310-38 |
| Makale Linki | http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=sag-1310-38 |
| Atıf Sayıları | |
| WoS | 16 |
| TRDizin | 2 |
| Google Scholar | 20 |
