Protective effect of infliximab on methotrexate induced liver injury in rats Unexpected drug interaction
Yazarlar (7)
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Cancer Research and Therapeutics |
| Dergi ISSN | 0973-1482 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 11 |
| Sayı | 1 |
| Sayfalar | 164 / 169 |
| DOI Numarası | 10.4103/0973-1482.140809 |
| Makale Linki | http://www.cancerjournal.net/text.asp?2015/11/1/164/140809 |
| Özet |
| Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity. Materials and Methods: For mtx group, the animals received an intraperitoneal single dose injection of mtx at a dose of 20 mg/kg. For inf group, the animals received an intraperitoneal single dose injection of inf at a dose of 7 mg/kg. For mtx + inf group, the single dose of inf at a dose of 7 mg/kg was given 72 h prior to mtx injection. After 72 h, a single dose of mtx 20 mg/kg was given. All rats were sacrificed 5 days after mtx injection. Results: TNF-alpha and nitric oxide (NO) levels of mtx group was significantly higher than the control (P < 0.001), inf (P < 0.001) and mtx + inf (P < 0.001) groups. Total score of histological damage was higher in the mtx group when compared with the mtx + inf group. Arginase and carbamoyl phosphate synthetase 1 (CPS-1) of mtx group was suppressed in comparison with the control group and was markedly increased in mtx + inf group. Conclusion: Inf may partially prevent mtx-induced hepatic damage in rats. However, the combined usage of mtx and inf increases arginase and CPS-1 enzyme activities and at the same time blocks TNF-alpha. This combination especially in cancer patients may lead to cancer cell invasion and metastasis. |
| Anahtar Kelimeler |
| Arginase | carbamoyl phosphate synthetase 1 | hepatotoxicity | infliximab | methotrexate |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 42 |
| SCOPUS | 48 |
| Google Scholar | 59 |