| Yazarlar (7) |
Erkan Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Levent Tümkaya
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Medine Cumhur Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Arif Yılmaz
|
|
Süleyman Yüce
|
| Özet |
| Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity. Materials and Methods: For mtx group, the animals received an intraperitoneal single dose injection of mtx at a dose of 20 mg/kg. For inf group, the animals received an intraperitoneal single dose injection of inf at a dose of 7 mg/kg. For mtx + inf group, the single dose of inf at a dose of 7 mg/kg was given 72 h prior to mtx injection. After 72 h, a single dose of mtx 20 mg/kg was given. All rats were sacrificed 5 days after mtx injection. Results: TNF-alpha and nitric oxide (NO) levels of mtx group was significantly higher than the control (P < 0.001), inf (P < 0.001) and mtx + inf (P < 0.001) groups. Total score of histological damage was higher in the mtx group when compared with the mtx + inf group. Arginase and carbamoyl phosphate synthetase 1 (CPS-1) of mtx group was suppressed in comparison with the control group and was markedly increased in mtx + inf group. Conclusion: Inf may partially prevent mtx-induced hepatic damage in rats. However, the combined usage of mtx and inf increases arginase and CPS-1 enzyme activities and at the same time blocks TNF-alpha. This combination especially in cancer patients may lead to cancer cell invasion and metastasis. |
| Anahtar Kelimeler |
| Arginase | carbamoyl phosphate synthetase 1 | hepatotoxicity | infliximab | methotrexate |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF CANCER RESEARCH AND THERAPEUTICS |
| Dergi ISSN | 0973-1482 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 11 |
| Sayı | 1 |
| Sayfalar | 164 / 169 |
| Doi Numarası | 10.4103/0973-1482.140809 |
| Makale Linki | http://www.cancerjournal.net/text.asp?2015/11/1/164/140809 |
| Atıf Sayıları | |
| WoS | 41 |
| Google Scholar | 48 |
