Topiramate ameliorates abdominal aorta cross clamping induced liver injury in rats
Yazarlar (9)
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Saudi Journal of Gastroenterology |
| Dergi ISSN | 1319-3767 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2014 |
| Cilt No | 20 |
| Sayı | 5 |
| Sayfalar | 297 / 303 |
| DOI Numarası | 10.4103/1319-3767.141690 |
| Makale Linki | http://www.saudijgastro.com/text.asp?2014/20/5/297/141690 |
| Özet |
| Background and Aim: Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-alpha) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury. Materials and Methods: Thirty male Wistar albino rats were divided into three groups: Control, I/R, and I/R plus TPM (I/R + TPM) groups. Laparotomy without I/R injury was performed in the control group. After laparotomy, cross-ligation of infrarenal abdominal aorta was applied for 2 h in I/R groups that was followed by 2 h of reperfusion. TPM (100 mg/kg/day) was orally administrated to the animals in the I/R + TPM group for seven consecutive days before I/R procedure. Results: The I/R group's TNF-alpha and interleukin-6 (IL-6) levels were significantly higher than those of the control (P = 0.010; P = 0.002) and I/R + TPM groups (P = 0.010; P = 0.002, respectively). Asymmetric dimethyl arginine (ADMA) levels of I/R group were higher than the control (P = 0.015) and I/R + TPM groups. I/R caused serious histopathological damage to liver tissue; however, TPM led to very low histopathological changes. Conclusion: Our data demonstrated that TPM treatment prominently decreases the severity of liver I/R injury. TPM pretreatment may have preventive effects on liver injury via I/R during intra-abdominal surgery. |
| Anahtar Kelimeler |
| Asymmetric dimethyl arginine | carbonic anhydrase II | ischemia reperfusion | liver | topiramate |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 16 |
| SCOPUS | 16 |
| Google Scholar | 22 |