Yazarlar |
Erkan Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Medine Cumhur Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Levent Tümkaya
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
İbrahim Aydın
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Arif Yılmaz
|
Süleyman Yüce
|
Fatih Mehmet Gökçe
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Özet |
Background and Aim: Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-alpha) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury. Materials and Methods: Thirty male Wistar albino rats were divided into three groups: Control, I/R, and I/R plus TPM (I/R + TPM) groups. Laparotomy without I/R injury was performed in the control group. After laparotomy, cross-ligation of infrarenal abdominal aorta was applied for 2 h in I/R groups that was followed by 2 h of reperfusion. TPM (100 mg/kg/day) was orally administrated to the animals in the I/R + TPM group for seven consecutive days before I/R procedure. Results: The I/R group's TNF-alpha and interleukin-6 (IL-6) levels were significantly higher than those of the control (P = 0.010; P = 0.002) and I/R + TPM groups (P = 0.010; P = 0.002, respectively). Asymmetric dimethyl arginine (ADMA) levels of I/R group were higher than the control (P = 0.015) and I/R + TPM groups. I/R caused serious histopathological damage to liver tissue; however, TPM led to very low histopathological changes. Conclusion: Our data demonstrated that TPM treatment prominently decreases the severity of liver I/R injury. TPM pretreatment may have preventive effects on liver injury via I/R during intra-abdominal surgery. |
Anahtar Kelimeler |
Asymmetric dimethyl arginine, carbonic anhydrase II, ischemia reperfusion, liver, topiramate |
Makale Türü | Özgün Makale |
Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
Dergi Adı | Saudi Journal of Gastroenterology |
Dergi ISSN | 1319-3767 |
Dergi Tarandığı Indeksler | SCI-Expanded |
Makale Dili | İngilizce |
Basım Tarihi | 01-2014 |
Cilt No | 20 |
Sayı | 5 |
Sayfalar | 297 / |
Doi Numarası | 10.4103/1319-3767.141690 |
Makale Linki | http://www.saudijgastro.com/text.asp?2014/20/5/297/141690 |
Atıf Sayıları | |
WoS | 14 |
Google Scholar | 20 |