| Yazarlar |
Erkan Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Medine Cumhur Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Levent Tümkaya
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
İbrahim Aydın
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Arif Yılmaz
|
|
Süleyman Yüce
|
|
Ahmet Fikret Yücel
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino rats were divided into three groups: control, I/R, and I/R+ADA, each group containing 10 animals. Laparotomy without I/R injury was performed in the control group animals. Laparotomy in the I/R group was followed by two hours of infrarenal abdominal aortic cross ligation and then two hours of reperfusion. ADA (50 mg/kg) was administered intraperitoneally as a single dose, to the I/R+ADA group, five days before I/R. The tumor necrosis factor-alpha (TNF-alpha) (pg/mg protein) and nitric oxide (NO) (mu mol/g protein) levels in the I/R group (430.8 +/- 70.1, 8.0 +/- 1.1, resp.) were significantly higher than those in the I/R+ADA group (338.0 +/- 71.6, P = 0.006; 6.3 +/- 1.2, P = 0.008) and the control group (345.5 +/- 53.3, P = 0.008; 6.5 +/- 1.5, P = 0.010, resp.). I/R causes severe histopathological injury to the liver tissue, but ADA leads to much less histopathological changes. ADA treatment significantly decreased the severity of liver I/R injury. ADA pretreatment may have protective effects on experimental liver injury. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BioMed Research International |
| Dergi ISSN | 2314-6133 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2014 |
| Cilt No | 2014 |
| Sayfalar | 1 / 8 |
| Doi Numarası | 10.1155/2014/907915 |
| Makale Linki | http://www.hindawi.com/journals/bmri/2014/907915/ |
| Atıf Sayıları | |
| WoS | 13 |
| Google Scholar | 13 |
