| Yazarlar (5) |
Kemal Türkyılmaz
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Veysi Öner
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Ayşegül Küçükali Türkyılmaz
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Serkan Kırbaş
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
| Özet |
| Purpose: To compare peripapillary retinal nerve fiber layer (RNFL) thicknesses measured by Cirrus HD optical coherence tomography (OCT) of patients with vitamin B12 deficiency with healthy controls and to evaluate the correlation between the peripapillary RNFL thickness and plasma vitamin B12 levels. Materials and Methods: Forty-five patients (19 male and 26 female) with a diagnosis of vitamin B12 deficiency (patient group) and 45 age-and sex-matched healthy subjects (control group) were consecutively enrolled in this study. Average, temporal, nasal, inferior, and superior quadrant peripapillary RNFL thicknesses of each subject were obtained using the Cirrus HD OCT. Disc area (DA) and rim area (RA), central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were also measured. Results: Mean age of each group was 33.1 +/- 6.5 years (range: 21-45 years). Mean plasma vitamin B12 level was 114.8 +/- 34.0 pg/mL in the patient group and was 405.1 +/- 20.0 pg/mL in the control group (p < 0.001). The patient and control groups were similar regarding axial length, plasma folate levels, DA, RA, CST, CV, CAT, and RNFL thicknesses in superior, nasal, and inferior quadrants. However, average RNFL and RNFL in temporal quadrant were significantly thinner in the patient group than in the control group (p = 0.013 and p < 0.001, respectively). In addition, temporal (r = 0.356, p = 0.001) and average (r = 0.212, p = 0.045) peripapillary RNFL thicknesses were correlated with plasma vitamin B12 levels. Conclusion: We have shown that, as in other non-glaucomatous optic neuropathies, temporal quadrant RNFL thickness was thinner in patients with vitamin B12 deficiency and it was correlated with plasma vitamin B12 levels. Further studies are warranted to clarify the clinical relevance of these findings and the effects of vitamin B12 replacement therapy. |
| Anahtar Kelimeler |
| vitamin B12 deficiency | peripapillary retinal nerve fiber layer thickness | spectral-domain optical coherence tomography | glaucoma | optic neuropathy |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CURRENT EYE RESEARCH |
| Dergi ISSN | 0271-3683 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2013 |
| Cilt No | 38 |
| Sayı | 6 |
| Sayfalar | 680 / 684 |
| Doi Numarası | 10.3109/02713683.2012.758291 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/02713683.2012.758291 |
| Atıf Sayıları | |
| WoS | 16 |
| Google Scholar | 23 |
