High Serum YKL 40 Level in Patients with COPD Is Related to Hypoxemia and Disease Severity
Yazarlar (8)
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Medical Park Hospital, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Tohoku Journal of Experimental Medicine |
| Dergi ISSN | 0040-8727 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2013 |
| Cilt No | 229 |
| Sayı | 2 |
| Sayfalar | 163 / 170 |
| DOI Numarası | 10.1620/tjem.229.163 |
| Makale Linki | http://japanlinkcenter.org/DN/JST.JSTAGE/tjem/229.163?lang=en&from=CrossRef&type=abstract |
| Özet |
| Chronic obstructive pulmonary disease (COPD) is a major health problem with increasing morbidity and mortality throughout the world. YKL-40 is a chitin-binding glycoprotein consisting of 383 amino acids, with a molecular mass of 40 kDa, and its serum level is elevated in inflammatory diseases. YKL-40 is a newly recognized biomarker of inflammation and has not been thoroughly investigated in COPD. The aim of the study is to investigate the relationship between serum YKL-40 levels and severity of COPD. The study population consisted of 52 patients with COPD with the mean age of 60.2 +/- 10.1 years. The serum YKL-40 level increased significantly with increasing age (p = 0.022, r = 0.346). In COPD patients, high serum YKL-40 level is correlated to low forced expiratory volume at 1 second (FEV1, percent of predicted) (r = -0.277, p = 0.047). Moreover, high serum YKL-40 level is correlated to low arterial oxygen pressure (PaO2, mmHg) (r = -0.387, p = 0.005). The mean serum YKL-40 level was found as 243.1 +/- 129.2 ng/ml in COPD patients with desaturation during 6-minute walk test (6MWT) and this value was higher than the mean serum YKL-40 level (155.8 +/- 59.1 ng/ml) of COPD patients without desaturation during 6MWT (p = 0.004). This study demonstrated that high serum YKL-40 levels were correlated to severity of COPD. We propose that circulating YKL-40 levels could be a biomarker for hypoxemia and decline in lung function. |
| Anahtar Kelimeler |
| chitin binding glycoprotein | chronic obstructive pulmonary disease | hypoxemia | inflammation | saturation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 16 |
| SCOPUS | 16 |
| Google Scholar | 31 |