| Yazarlar |
Aziz Gümüş
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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Servet Kayhan
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Halit Çınarka
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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Bulmuş Necati
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Yavuz Asiye
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Ünal Sabin
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Şevket Özkaya
Bahçeşehir Üniversitesi, Türkiye |
| Özet |
| Chronic obstructive pulmonary disease (COPD) is a major health problem with increasing morbidity and mortality throughout the world. YKL-40 is a chitin-binding glycoprotein consisting of 383 amino acids, with a molecular mass of 40 kDa, and its serum level is elevated in inflammatory diseases. YKL-40 is a newly recognized biomarker of inflammation and has not been thoroughly investigated in COPD. The aim of the study is to investigate the relationship between serum YKL-40 levels and severity of COPD. The study population consisted of 52 patients with COPD with the mean age of 60.2 +/- 10.1 years. The serum YKL-40 level increased significantly with increasing age (p = 0.022, r = 0.346). In COPD patients, high serum YKL-40 level is correlated to low forced expiratory volume at 1 second (FEV1, percent of predicted) (r = -0.277, p = 0.047). Moreover, high serum YKL-40 level is correlated to low arterial oxygen pressure (PaO2, mmHg) (r = -0.387, p = 0.005). The mean serum YKL-40 level was found as 243.1 +/- 129.2 ng/ml in COPD patients with desaturation during 6-minute walk test (6MWT) and this value was higher than the mean serum YKL-40 level (155.8 +/- 59.1 ng/ml) of COPD patients without desaturation during 6MWT (p = 0.004). This study demonstrated that high serum YKL-40 levels were correlated to severity of COPD. We propose that circulating YKL-40 levels could be a biomarker for hypoxemia and decline in lung function. |
| Anahtar Kelimeler |
| chitin binding glycoprotein, chronic obstructive pulmonary disease, hypoxemia, inflammation, saturation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | The Tohoku Journal of Experimental Medicine |
| Dergi ISSN | 1349-3329 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Cilt No | 229 |
| Sayı | 2 |
| Sayfalar | 163 / 170 |
| Doi Numarası | 10.1620/tjem.229.163 |
| Makale Linki | http://japanlinkcenter.org/DN/JST.JSTAGE/tjem/229.163?lang=en&from=CrossRef&type=abstract |
| Atıf Sayıları | |
| WoS | 14 |
| Google Scholar | 25 |
