Effects of lisinopril on NMDA receptor subunits 2A and 2B levels in the hippocampus of rats with l NAME induced hypertension
Yazarlar (5)
Recep Sutcu
İzmir Kâtip Çelebi Üniversitesi, Türkiye
İzmir Kâtip Çelebi Üniversitesi, Türkiye
Prof. Dr. Aynur KIRBAŞ Recep Tayyip Erdogan University, Türkiye
Serkan Kirbas Recep Tayyip Erdogan University, Türkiye
Suleyman Kutluhan
Süleyman Demirel Üniversitesi, Türkiye
Süleyman Demirel Üniversitesi, Türkiye
Namik Delibas Yozgat Bozok University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Receptors and Signal Transduction (Q4) | ||
| Dergi ISSN | 1079-9893 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2012 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 03-09-2012 |
| Cilt / Sayı / Sayfa | 32 / 5 / 279–284 | DOI | 10.3109/10799893.2012.714788 |
| Makale Linki | http://informahealthcare.com/doi/abs/10.3109/10799893.2012.714788 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Hypertension is major risk factor leading to cerebrovascular pathologies. N-methyl d-aspartate receptors (NMDARs) and renin-angiotensin system are involved in neuronal plasticity, as well as cognitive functions in the hippocampus. In this study, we examined the effects of lisinopril, an ACE inhibitor, on the levels of hippocampal NMDAR subunits; NR2A and NR2B in l-NAME (Nϵ-nitro-l-arginine Methyl Ester)-induced hypertensive rats. In addition, malondialdehyde (MDA) levels were measured as a marker for lipid peroxidation. Compared with the control group, the MDA level was significantly increased after 8 weeks in the l-NAME-treated group. Rats treated with lisinopril and l-NAME plus lisinopril were found to have significantly decreased hippocampal MDA levels. Regarding the hippocampal concentrations of NR2A and NR2B, there were no statistically significant differences between groups. We demonstrated … |
| Anahtar Kelimeler |
| ACE inhibitor(s) | Hippocampus | Hypertension | Lipid peroxidation | NMDAR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 1 |
| Google Scholar | 3 |