| Yazarlar (9) |
Çanga Aytun
|
|
Mustafa Çetin
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Kocaman Sinan Altan
|
|
Murtaza Emre Durakoğlugil
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Turan Erdoğan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Ahmet Temiz
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Adnan Yılmaz
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Yüksel Çiçek
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
| Özet |
| Slow coronary flow (SCF) is an angiographic finding characterized by delayed opacification of the epicardial coronary arteries without obstructive coronary disease. Resistin, an adipocytokine, plays a major role besides low-grade inflammation in atherosclerotic vascular processes and may be of importance in other coronary pathologies such as SCF. The present study was cross-sectional and observational, consisting of 70 individuals who underwent coronary angiography and had angiographically normal coronary arteries of varying coronary flow rates. The study included 50 patients with isolated SCF and 20 control participants with normal coronary flow (NCF). There were no statistically significant differences between the SCF and NCF groups with respect to age, gender, presence of hypertension or diabetes mellitus, and smoking habit, except for increased creatinine levels (p = 0.014). The serum resistin level was significantly higher in the SCF group than in the NCF group (8.4 +/- 7.2 vs. 5.4 +/- 2.6 ng/ml, p = 0.014). Ln-transformed resistin levels correlated positively with left anterior descending (LAD) coronary artery TIMI frame count (TFC) (r = 0.408, p < 0.001) as well as with glucose (r = 0.340, p = 0.004), creatinine (r = 0.248, p = 0.044), and C-reactive protein (CRP; r = 0.283, p = 0.023) levels, and negatively with LAD coronary flow velocity (r = -aEuro parts per thousand 0.314, p = 0.009). When multivariate analyses were performed, in linear regression analysis, ln-resistin was associated with a longer TFC [beta (standardized regression coefficient): 0.404, p = 0.001] and lower coronary flow velocity (beta: -aEuro parts per thousand 0.280, p = 0.035); in logistic regression analysis, ln-resistin was an independent predictor of the presence of SCF (OR: 6.692, 65 %CI: 1.117-40.1, p = 0.037). We demonstrated, for the first time, a significant increase in serum resistin levels in patients with SCF compared to subjects with NCF. We believe that further studies are needed to clarify the role of resistin in patients with SCF. |
| Anahtar Kelimeler |
| Slow coronary flow | Resistin | Adipokines | C-reactive protein | Coronary angiography |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | HERZ |
| Dergi ISSN | 0340-9937 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2013 |
| Cilt No | 38 |
| Sayı | 7 |
| Sayfalar | 773 / 778 |
| Doi Numarası | 10.1007/s00059-013-3758-6 |
| Makale Linki | http://link.springer.com/10.1007/s00059-013-3758-6 |
| Atıf Sayıları | |
| WoS | 14 |
| Google Scholar | 23 |
