| Yazarlar (9) |
Medine Cumhur Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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Erkan Cüre
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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Levent Tümkaya
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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İbrahim Aydın
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Hasan Efe
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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İbrahim Şehitoğlu
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
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Süleyman Yüce
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| Özet |
| Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. Methods: A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion. TPM (100 mg/kg/day) was orally administrated to animals in the I/R+TPM group for seven consecutive days before I/R. Results: The I/R group's TNF-a and interleukin-1 beta (IL-1(3) levels were significantly higher (1184.2 +/- 129.1 pg/mg protein; 413.1 +/- 28.8 pg/mg protein, respectively) than those of the control (907.8 +/- 113.0 pg/mg protein, p = 0.002; 374.7 +/- 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 +/- 115.2 pg/mg protein, p < 0.001; 377.9 +/- 30.9 pg/mg protein, p = 0.007, respectively). Conclusion: TPM may partially prevent renal damage in rats. The opening of new horizons of this kind of knowledge will help understand the complex challenge in the prevention of renal I/R damage (Tab. 1, Fig. 3, Ref. 42). Text in PDF www.elis.sk. |
| Anahtar Kelimeler |
| topiramate | ischemia reperfusion | kidney | carbonic anhydrase II |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY |
| Dergi ISSN | 0006-9248 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 116 |
| Sayı | 4 |
| Sayfalar | 259 / 263 |
| Doi Numarası | 10.4149/BLL_2015_050 |
| Atıf Sayıları | |
| WoS | 11 |
| Google Scholar | 11 |
