Topiramate has protective effect on renal injury
Yazarlar (9)
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Bratislava Medical Journal |
| Dergi ISSN | 0006-9248 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 116 |
| Sayı | 4 |
| Sayfalar | 259 / 263 |
| DOI Numarası | 10.4149/BLL_2015_050 |
| Özet |
| Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. Methods: A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion. TPM (100 mg/kg/day) was orally administrated to animals in the I/R+TPM group for seven consecutive days before I/R. Results: The I/R group's TNF-a and interleukin-1 beta (IL-1(3) levels were significantly higher (1184.2 +/- 129.1 pg/mg protein; 413.1 +/- 28.8 pg/mg protein, respectively) than those of the control (907.8 +/- 113.0 pg/mg protein, p = 0.002; 374.7 +/- 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 +/- 115.2 pg/mg protein, p < 0.001; 377.9 +/- 30.9 pg/mg protein, p = 0.007, respectively). Conclusion: TPM may partially prevent renal damage in rats. The opening of new horizons of this kind of knowledge will help understand the complex challenge in the prevention of renal I/R damage (Tab. 1, Fig. 3, Ref. 42). Text in PDF www.elis.sk. |
| Anahtar Kelimeler |
| topiramate | ischemia reperfusion | kidney | carbonic anhydrase II |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 11 |
| SCOPUS | 12 |
| Google Scholar | 16 |