| Yazarlar |
Ahmet Kıvrak
Türkiye |
Dr. Öğr. Üyesi Alp YILDIRIM
Türkiye |
Dr. Öğr. Üyesi Levent HOROZ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Galip BELTİR
Türkiye |
| Özet |
| Background and objectiveIt has been suggested that knee osteoarthritis (KOA) is associated with the development of calcification and an increased risk of cardiovascular (CV) disease, while the contribution of KOA grade is not clearly known enough. This study aimed to investigate the relationship between the grade of KOA, the echocardiographic calcification score (echo-CCS), and CV risk assessment.MethodsThis cross-sectional study involved 204 patients diagnosed with KOA and classified according to the Kellgren-Lawrence staging criteria. Echo-CCS was obtained according to the presence of calcification in the aortic valve, aortic root, mitral ring, papillary muscle and ventricular septum. Framingham risk score (FRS) was used for CV risk assessment.ResultsCalcification was detected in 79.4% of patients. The median FRS, echo-CCS, and high-sensitivity C-reactive protein (hs-CRP) levels increased as the KOA grade increased (p<0.05). A one-grade increase in KOA increased the odds of echo-CCS 1-2 group by 5.15 fold (vs. no calcification group) (OR=5.15, p=0.003), while it increased the odds of echo-CCS >= 3 group by 4.61 fold (vs. echo-CCS 1-2 group) (OR=4.61, p=0.003). Median echo-CSS and hs-CRP were higher in the high CV risk group than in the moderate and low CV risk groups.ConclusionThe majority of patients with KOA had intracardiac calcification. An increased KOA grade was associated with higher echo-CSS and FRS. These findings indicate that patients with higher grades of KOA may be predisposed to developing subclinical atherosclerosis. |
| Anahtar Kelimeler |
| osteoarthritis | joint disease | echocardiography | cardiac disease | calcification |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | CUREUS JOURNAL OF MEDICAL SCIENCE |
| Dergi ISSN | 2168-8184 |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2023 |
| Cilt No | 15 |
| Sayı | 11 |
| Sayfalar | 1 / 12 |
| Doi Numarası | 10.7759/cureus.48869 |
| Makale Linki | http://dx.doi.org/10.7759/cureus.48869 |
| Atıf Sayıları |
