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Solvent-free synthesis of chiral Schiff-base ligands based on ferrocene under microwave irradiation and application to enantioselective nitroaldol (Henry) reaction  
Yazarlar
Gülşen Öztürk
Dicle Üniversitesi, Turkey
Mehmet Çolak
Dicle Üniversitesi, Turkey
Prof. Dr. Nadir DEMİREL Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Özet
Chiral Schiff-bases 3a-f based on ferrocene were designed and synthesized using solvent-free methods by mixing ferrocene carbaldehyde 1 with amino alcohols and amines 2a-f under microwave irradiation and classical method for the enantioselective nitroaldol (Henry) reaction. The Schiff-bases were obtained in shorter reaction times and improved yield under microwave irradiation method over classical method. The highest enantioselectivity was observed in ligand 3e (95% ee) when CH2Cl2 was used as solvent. © 2011 Wiley-Liss, Inc.
Anahtar Kelimeler
chiral Schiff-bases | ferrocene | Henry reaction | microwave irradiation | nitro aldol reaction
Makale Türü Özgün Makale
Makale Alt Türü SCOPUS dergilerinde yayımlanan tam makale
Dergi Adı Chirality
Dergi ISSN 0899-0042
Makale Dili İngilizce
Basım Tarihi 05-2011
Cilt No 23
Sayı 5
Sayfalar 374 / 378
Doi Numarası 10.1002/chir.20934