The Protective Effect of Adalimumab on Renal Injury in a Model of Abdominal Aorta Cross Clamping
Yazarlar (9)
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Advances in Clinical and Experimental Medicine |
| Dergi ISSN | 1899-5276 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2016 |
| Cilt No | 25 |
| Sayı | 2 |
| Sayfalar | 219 / 226 |
| DOI Numarası | 10.17219/acem/33250 |
| Makale Linki | http://www.advances.am.wroc.pl/strona.php?id=11&n=1882&lang=en |
| Özet |
| Background. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. The aim of this study was to investigate the possible protective effects of ADA on oxidative stress and cellular damage on rat kidney tissue after ischemia/reperfusion (I/R). Material and Methods. A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus ADA (I/R + ADA); each group comprised 10 animals. The control group underwent laparotomy without I/R injury. After undergoing laparotomy, I/R groups underwent two hours of infrarenal abdominal aortic cross ligation, which was followed by two hours of reperfusion. ADA (50 mg/kg) was administered as a single dose, intraperitoneally, to the I/R + ADA group, 5 days before I/R. Results. The I/R group's TNF-alpha (1150.9 +/- 145.6 pg/mg protein), IL-1 beta (287.0 +/- 32.4 pg/mg protein) and IL-6 (1085.6 +/- 56.7 pg/mg protein) levels were significantly higher than those of the control (916.1 +/- 88.7 pg/mg protein, + ADA groups (864.2 +/- 169.4 pg/mg protein, p = 0.003; 241.4 +/- 33.4 pg/mg protein, p = 0.010; 987.7 +/- 66.5 pg/mg protein, p = 0.004, respectively). To date, a few histopathological changes have been reported regarding renal I/R injury in rats due to ADA treatment whereas I/R caused severe histopathological injury to kidney tissue. Conclusions. ADA treatment significantly attenuated the severity of kidney I/R injury, inhibiting I/R-induced oxidative stress and renal damage. Because of its anti-inflammatory and antioxidant effects, ADA pretreatment may have protective effects on experimental kidney injury |
| Anahtar Kelimeler |
| ischemia | reperfusion injury | adalimumab | carbonic anhydrases | tumor necrosis factor alpha |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 13 |
| SCOPUS | 15 |
| Google Scholar | 16 |