Infliximab Modulates Cisplatin-Induced Hepatotoxicity in Rats
Yazarlar (9)
Medine Cumhur Cüre Recep Tayyip Erdogan University, Türkiye
Erkan Cüre Recep Tayyip Erdogan University, Türkiye
Yıldıray Kalkan
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Aynur KIRBAŞ Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Levent Tümkaya Recep Tayyip Erdogan University, Türkiye
Öğr. Gör. Arif Yılmaz Recep Tayyip Erdogan University, Türkiye
Ayşegül Küçükali Türkyılmaz Recep Tayyip Erdogan University, Türkiye
İbrahim Şehitoğlu
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Süleyman Yüce Rize Devlet Hastanesi, Türkiye
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Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Balkan Medical Journal (Q4) | ||
| Dergi ISSN | 2146-3123 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2016 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 03-10-2016 |
| Cilt / Sayı / Sayfa | 33 / 5 / 504–511 | DOI | 10.5152/balkanmedj.2016.150576 |
| Makale Linki | DOI : 10.5152/balkanmedj.2016.150576 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Background Cisplatin (Cis) is one of the most commonly used antineoplastic drugs. It is used as chemotherapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary cancers. Infliximab blocks tumor necrosis factor alpha (TNF-α). Several studies have reported that infliximab ameliorates cell damage by reducing cytokine levels. Aims We aimed to investigate whether infliximab has a preventive effect against cisplatin-induced hepatotoxicity and whether it has a synergistic effect when combined with Cis. Study Design Animal experimentation. Methods Male Wistar albino rats were divided in three groups as follows: Cis group, infliximab + Cis (CIN) group and the control group. Each group comprised 10 animals. Animals in the Cis group received an intraperitoneal single-dose injection of Cis (7 mg/kg). In the CIN group, a single dose of infliximab (7 mg/kg) was administered 72 h prior to the Cis injection. After 72 h, a single dose of Cis (7 mg/kg) was administered. All rats were sacrificed five days after Cis injection. Results TNF-α levels in the Cis group were significantly higher (345.5±40.0 pg/mg protein) than those of the control (278.7±62.1 pg/mg protein, p=0.003) and CIN groups (239.0±64.2 pg/mg protein, p=0.013). The Cis group was found to have high carbonic anhydrase (CA)-II and low carbamoyl phosphate synthetase-1 (CPS-1) levels. Aspartate transaminase (AST) and alanine transaminase (ALT) levels were lower in the CIN group as compared to the Cis group. Total histological damage was greater in the Cis group as compared to the control and CIN groups. Conclusion Cis may lead to … |
| Anahtar Kelimeler |
| Carbamoyl-phosphate synthetase 1 | Carbonic anhydrase | Cisplatin | Hepatotoxicity | Infliximab | Tumor necrosis factor alpha |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 29 |
| Scopus | 27 |
| Google Scholar | 41 |