Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue
Yazarlar (7)
K. İrak
Siirt Üniversitesi, Türkiye
Siirt Üniversitesi, Türkiye
Öy Çelik
Siirt Üniversitesi, Türkiye
Siirt Üniversitesi, Türkiye
Prof. Dr. Memiş BOLACALI Kırşehir Ahi Evran Üniversitesi, Türkiye
T. Tufan
Siirt Üniversitesi, Türkiye
Siirt Üniversitesi, Türkiye
S. Özcan
Siirt Üniversitesi, Türkiye
Siirt Üniversitesi, Türkiye
S. Yıldırım
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
I. Bolat
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Polish Journal of Veterinary Sciences (Q3) | ||
| Dergi ISSN | 2300-2557 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2024 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 27 / 1 / 95–105 | DOI | 10.24425/pjvs.2024.149339 |
| Makale Linki | 10.24425/pjvs.2024.149339 | ||
| Özet |
| Arsenic is an important metalloid that can cause poisoning in humans and domestic animals. Exposure to arsenic causes cell damage, increasing the production of reactive oxygen species. Chitosan is a biopolymer obtained by deacetylation of chitin with antioxidant and metal ion chelating properties. In this study, the protective effect of chitosan on arsenic-induced nephrotoxicity and oxidative damage was investigated. 32 male Wistar-albino rats were divided into 4 groups of 8 rats each as control group (C), chitosan group (CS group), arsenic group (AS group), and arsenic+ chitosan group (AS+ CS group). The C group was given distilled water by oral gavage, the AS group was given 100 ppm/day Na-arsenite ad libitum with drinking water, the CS group was given 200 mg/kg/day chitosan dissolved in saline by oral gavage, the AS+ CS group was given 100 ppm/day Na-arsenite ad libitum with drinking water and 200 mg/kg/day chitosan dissolved in saline by oral gavage for 30 days. At the end of the 30-day experimental period, 90 mg/kg ketamine was administered intraperitoneally to all rats, and blood samples and kidney tissues were collected. Urea, uric acid, creatinine, P, Mg, K, Ca, Na, Cystatin C (CYS-C), Neutrophil Gelatinase Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) levels were measured in serum samples. Malondialdehyde (MDA), Glutathione (GSH), Catalase (CAT) and Superoxide dismutase (SOD) levels in the supernatant obtained from kidney tissue were analyzed by ELISA method. Compared with AS group, uric acid and creatinine levels of the AS+ CS group were significantly decreased (p< 0.001), urea … |
| Anahtar Kelimeler |
| Arsenic | chitosan | nephrotoxicity | oxidative stress | rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |
| Scopus | 2 |