Investigation of the Effect of Silver Nanoparticles Obtained from Primula Vulgaris Extracts by Applying the Green Synthesis Method on MCF-7 Cells
Yazarlar (5)
Prof. Dr. Harun ÇİFTÇİ Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Çiğdem ER ÇALIŞKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Burcu Yazıcı Kırşehir Ahi Evran Üniversitesi
Akın Tekcan Amasya Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kübra ÖZTÜRK Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Iranian Journal of Chemistry and Chemical Engineering (Q3) | ||
| Dergi ISSN | 1021-9986 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2024 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 43 / 7 / 2556–2571 | DOI | 10.30492/IJCCE.2024.2001893.6020 |
| Makale Linki | http://www.ijcce.ac.ir/article_711 | ||
| Özet |
| In recent years, the use of nanoparticles has gained significant attention in cancer research due to their unique properties and potential as targeted drug delivery systems. This study focuses on the synthesis and characterization of Primula vulgaris stabilized silver nanoparticles (PVAgNPs) and the evaluation of in vitro cytotoxicity against MCF-7 cells. In this study, PVAgNPs were synthesized separately from the flower (PVAgNPsF), leaf (PVAgNPsL), and root (PVAgNPsR) extracts of Primula vulgaris (PV). The PVAgNPs were characterized by various analytical techniques, including UV-Visible absorption spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction, Dynamic Light Scattering (DLS), zeta potential, and scanning electron microscopy (SEM). The maximum absorption wavelengths are obtained at 437 nm for the PVAgNPsR samples and at 440 nm for the PVAgNPsF and PVAgNPsL samples. Based on the XRD spectra, PVAgNPs were found to have a cubic crystal structure. On average, the zeta potential values of PVAgNPs ranged from-14 to-28 mV, indicating that they were quite stable. SEM analysis showed that the synthesized PVAgNPs were predominantly spherical in shape and ranged in size from 40 to 89 nm. The iCELLigence Real-Time Cell Analysis (RTCA) system was used to evaluate the efficacy of the synthesized PVAgNPs against MCF-7 cell lines. After 24 h of incubation, the inhibitory concentrations (IC50) of PVAgNPsL PVAgNPsR, and PVAgNPsF |
| Anahtar Kelimeler |
| Cytotoxic effects | Green synthesis | MCF-7 | Primula vulgaris | Silver nanoparticles |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 2 |
| Scopus | 2 |