Treatment of cervical cancer by electrochemotherapy with bleomycin, cisplatin, and calcium: an in vitro experimental study
Yazarlar (3)
Dr. Öğr. Üyesi Güney GÜRSOY Kırşehir Ahi Evran Üniversitesi, Türkiye
Zehra Çiçek Sağlık Bilimleri Üniversitesi, Türkiye
Meriç Arda Eşmekaya Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Medical Oncology (Q2) | ||
| Dergi ISSN | 1357-0560 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2023 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 40 / 1 / 16–0 | DOI | 10.1007/s12032-022-01921-7 |
| Makale Linki | http://dx.doi.org/10.1007/s12032-022-01921-7 | ||
| Özet |
| Low-dose chemotherapy in advanced stages of cancer does not give a positive response in treatment. The use of high-dose antineoplastic drugs creates significant side effects. The limiting situation in treatment creates a need for new generation drugs with less side effects and new treatment methods that will enable low-dose drug use. Electroporation (EP), a phenomenon, is a technique in which the membrane permeability is increased by the establishment of hydrophilic pores in the cell membrane with short and high-voltage electrical pulses. In the present investigation study, we aimed to inspect the effects of EP plus bleomycin, cisplatin, and calcium administration (CaEP) on cell viability, apoptotic activity, gene expression p53, Bax/Bcl-2 rate mitochondrial membrane potential (ΔΨm), and cell cycle in HeLa cervical cancer cell line. The permeabilization of the membrane was evaluated in flow cytometry with the … |
| Anahtar Kelimeler |
| Cell cycle | Cell viability | Cervical cancer treatment | Electrochemotherapy | Electroporation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 9 |
| Scopus | 5 |
| Web of Science | 8 |