| Yazarlar |
Prof. Dr. Figen TUNCAY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Pınar Borman
Ankara Medipol Üniversitesi, Türkiye |
|
Seher Kocaoğlu
Türkiye |
|
Zeynep Rezan Yorgancıoğlu
|
| Özet |
| Objective: The aim of this study was to determine autonomic nerve system (ANS) functions by using clinical and electrophysiological tests of ANS in rheumatoid arthritis (RA) patients. We also examined relations between the disease activity and indicators of autonomic activity. Material and Methods: Twenty-five RA patients and 25 healthy control subjects were recruited to the study. Data about demographic characteristics of the subjects and disease characteristics of the RA patients were determined. A detailed neurological examination was performed in all subjects and the clinical autonomic symptoms were recorded. Clinical and electrophysiological assessments of ANS were performed in all subjects. Clinical measurements including the heart rate variation with deep breathing (HRV), heart rate response to standing (HRS) were used to assess the parasympathetic functions. The systolic blood pressure response to standing (SBP) and diastolic blood pressure response to isometric exercise (DBP) were obtained to assess sympathetic nervous functions of the subjects. The electrophysiological evaluation of ANS were performed by sympathethic skin response (SSR) and R-R Interval variation (RRIV) measurements for the sympathetic and parasympathetic functions respectively. Patients with RA were subdivided into two groups depending on the activity of disease. The difference between the groups and relationship between ANS variables and clinical entities were determined. Results: Nineteen female, 6 male RA patients with a mean age of 48.3 ± 13.1 years and 10 male, fifteen female healthy control subjects with a mean age of 42.4 ± 14.8 years were included to the study. All the subjects were totally symptom free for ANS involvement and subjects in both groups and had normal neurological examination findings. The levels of HRV, HRS and the mean RRIV values were significantly lower in RA patients than in control subjects. The clinical ANS parameters of the patients having more active disease were statistically different than in subjects with mild disease in regard to HRV values and R%, D% (6.1 ± 2.9 vs 9.3 ± 3.5, 9.4 ± 9 vs 27.1 ± 25.1, 23 ± 21.1 vs 42.6 ± 25, respectively, p< 0.05). Conclusion: In our study we have found significant differences in values of HRV and HRS in clinical ANS tests along with a decrease in RRIV determined by electrophysiological tests, in RA patients free of symptoms for ANS involvement. This indicates a subclinical parasympathethic dysfunction of ANS in patients with RA which may be related with disease activity. Copyright © 2009 by Türk Tibbi Rehabilitasyon Kurumu Derneǧi. |
| Anahtar Kelimeler |
| Arthritis | Autonomic nervous system | Parasympathetic nervous system | Rheumatoid | Sympathetic nervous system |
| Bildiri Türü | Tebliğ/Bildiri |
| Bildiri Alt Türü | Özet Metin Olarak Yayımlanan Tebliğ (Uluslararası Kongre/Sempozyum) |
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum |
| Bildiri Dili | İngilizce |
| Kongre Adı | 13th European Congress of Clinical Neurophysiology 4-8 May, Istanbul, Turkey, 2008. |
| Kongre Tarihi | 04-05-2008 / |
| Basıldığı Ülke | |
| Basıldığı Şehir |
