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Glucagon-Like Peptide 1, Insulin, Sensory Neurons, and Diabetic Neuropathy   
Yazarlar
Doç. Dr. Mustafa KAN
Kırşehir Ahi Evran Üniversitesi
GuiFang Guo
Bhagat Singh
Vandana Singh
Douglas W. Zochodne
Özet
Like insulin, glucagon-like peptide 1 (GLP-1) may have direct trophic actions on the nervous system, but its potential role in supporting diabetic sensory neurons is uncertain. We identified wide expression of GLP-1 receptors on dorsal root ganglia sensory neurons of diabetic and nondiabetic mice. Exendin-4, a GLP-1 agonist, increased neurite outgrowth of adult sensory neurons in vitro. To determine the effects of exendin-4 in comparison with continuous low-or high-dose insulin in vivo, we evaluated parallel cohorts of type 1 (streptozotocin-induced) and type 2 (db/db) mice of 2 months' diabetes duration with established neuropathy during an additional month of treatment. High-dose insulin alone reversed hyperglycemia in type 1 diabetic mice, partly reversed thermal sensory loss, improved epidermal innervation but failed to reverse electrophysiological abnormalities. Exendin-4 improved both sensory electrophysiology and behavioral sensory loss. Low-dose insulin was ineffective. In type 2 diabetes, hyperglycemia was uncorrected, and neither insulin nor exendin-4 reversed sensory electrophysiology, sensory behavior, or loss of epidermal axons. However, exendin-4 alone improved motor electrophysiology. Receptor for advanced glycosylated end products and nuclear factor-kappa B neuronal expression were not significantly altered by diabetes or treatment. Taken together, these results suggest that although GLP-1 agonists and insulin alone are insufficient to reverse all features of diabetic neuropathy, in combination, they might benefit some aspects of established diabetic neuropathy.
Anahtar Kelimeler
Diabetes mellitus | Diabetic neuropathy | Exendin-4 | Glucagon-like peptide 1 | Insulin | Polyneuropathy
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Dergi ISSN 0022-3069
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 06-2012
Cilt No 71
Sayı 6
Sayfalar 494 / 510
Doi Numarası 10.1097/NEN.0b013e3182580673
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 62
Glucagon-Like Peptide 1, Insulin, Sensory Neurons, and Diabetic Neuropathy

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