Novel bis-crown ethers and their sodium complexes as antimicrobial agent: synthesis and spectroscopic characterizations
Yazarlar (4)
Ankara University, Türkiye
Ankara University, Türkiye
Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Gazi University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MEDICINAL CHEMISTRY RESEARCH (Q4) | ||
| Dergi ISSN | 1054-2523 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2014 |
| Cilt / Sayı / Sayfa | 23 / 8 / 3652–3661 | DOI | 10.1007/s00044-014-0937-9 |
| Özet |
| A series of new compounds containing formyl and imine group were synthesized. New formyl-substituted compounds were prepared by the reaction of 1,2-bis(bromomethyl)benzene with benzaldehyde derivatives in the presence of NaOH. New bis-crown ether imine compounds were prepared by the condensation of corresponding aldehydes with 4'-aminobenzo-15-crown-5. Sodium complexes of the bis-crown ethers form crystalline 2:1 (Na+:ligand) stoichiometries were also been synthesized. The prepared compounds were structurally confirmed by analytical and spectral data and evaluated for their antibacterial and antifungal activities. The results show that the antibacterial activity of compounds including o-methoxy group was significantly higher against S. epidermis compared to the other studied antimicrobial group. |
| Anahtar Kelimeler |
| bis-Crown ethers | Schiff bases | Aldehydes | Antibacterial activity | Sodium complexes |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 16 |