| Yazarlar |
Kürşat Gündoğan
Türkiye |
|
Emre Karakoç
Türkiye |
|
Turgut Teke
Türkiye |
Dr. Öğr. Üyesi Avşar ZERMAN
Türkiye |
|
Aliye Esmaoglu
|
|
Şahin Temel
Türkiye |
|
Muhammet Güven
Türkiye |
|
Murat Sungur
Türkiye |
| Özet |
| Background/aim: Critically ill patients are at risk of developing gastrointestinal (GI) bleeding due to stress causing mucosal damage.Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleedingin low risk critically ill patients.Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit (ICU)patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group(received oral/EN plus pantoprazole) and control group (received only oral/EN).Results: A total of 300 patients (intervention group: 152, control group: 148) participated in the study. Overall, 226 (75%) patients werefed by orally and 74 (25%) patients fed by enteral tube feeding. Median duration of nutritional support 4 (range: 2–33) days. Overt upperGI bleeding was noted only in one patient (0.65%) who was in the intervention group. The overall length of ICU stay of 4 (2–105) days,while ICU stay was significantly longer in the intervention group than in the control group (P = 0.006).Conclusions: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritionalsupport, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event (GI bleeding) rateand limited power. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Turkish Journal of Medical Sciences |
| Dergi ISSN | 1300-0144 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2020 |
| Cilt No | 50 |
| Sayı | 4 |
| Sayfalar | 776 / 783 |
| Doi Numarası | 10.3906/sag-1911-42 |
| Atıf Sayıları |
