| Yazarlar (7) |
Mehmet Gümüş
Türkiye |
|
İrfan Koca
Türkiye |
|
Yusuf Sert
Türkiye |
|
Ali Dişli
Türkiye |
|
Ezgi Nurdan Yenilmez Tunoğlu
Türkiye |
Dr. Öğr. Üyesi Lütfi TUTAR
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Yusuf Tutar
Türkiye |
| Özet |
| Intensive studies on hepatocellular carcinoma (HCC), which is spreading rapidly around the world and has a high mortality rate, is due to the lack of adequate preventive or curative treatment methods. Treating patients with HCC has become very challenging because of the heterogeneity in the patient population lead activation of different signaling pathways, and pathway crosstalk for patients. Therefore, understanding these molecular mechanisms and combining drugs with molecular therapies to overcome these drawbacks has become an area of utmost importance. In this study, the biological activities of the designed and characterized triad Pyrazole–Thiazol–Coumarin (PTC) compounds were determined by performing cell viability, qPCR array, apoptosis and cell cycle assays. One of the compounds (PTC10) implicitly suppresses multiple pathways (RAS/MAP kinase and PI3K-AKT) simultaneously. This action is … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS |
| Dergi ISSN | 0739-1102 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2023 |
| Cilt No | 41 |
| Sayı | 23 |
| Sayfalar | 14382 / 14397 |
| Doi Numarası | 10.1080/07391102.2023.2181643 |
| Makale Linki | http://dx.doi.org/10.1080/07391102.2023.2181643 |
| Atıf Sayıları | |
| Google Scholar | 14 |
