| Yazarlar (8) |
Barış Çıplak
Türkiye |
|
Eyüp Gökhan Turmuş
Türkiye |
Dr. Öğr. Üyesi Özlem KARA
Türkiye |
|
Gülçin Dağlıoğlu
Türkiye |
|
Mehmet Murat Altındağ
|
|
Ömer Yavuz Şimşek
Türkiye |
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Prof. Dr. Mustafa KARA
Türkiye |
| Özet |
| The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats' malondialdehyde, catalase, and superoxide dismutase levels were determined. The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001). The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models. |
| Anahtar Kelimeler |
| Cisplatin | Resveratrol | Rat | Ovary |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Rev. Assoc. Med. Bras. |
| Dergi ISSN | 0104-4230 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2023 |
| Cilt No | 69 |
| Sayı | 3 |
| Sayfalar | 1 / 6 |
| Doi Numarası | 10.1590/1806-9282.20230314 |
| Makale Linki | chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.scielo.br/j/ramb/a/QPqsqXjBYMKLnZSzxFmmHJs/?format=pdf&lang=en |
| Atıf Sayıları | |
| WoS | 3 |
| Google Scholar | 3 |
