Does resveratrol reduce cisplatin-induced ovarian damage?
Yazarlar (8)
Barış Çıplak
Malatya State Hospital, Türkiye
Eyüp Gökhan Turmuş
Ye5ilyurt Hasan Calik State Hosp, Türkiye
Doç. Dr. Özlem KARA
Kırşehir Ahi Evran Üniversitesi, Türkiye
Gülçin Dağlıoğlu
Cukurova University, Türkiye
Mehmet Murat Altındağ
Malatya State Hospital, Türkiye
Ömer Yavuz Şimşek
Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Mustafa KARA
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (Q2) | ||
| Dergi ISSN | 0104-4230 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 69 / 8 / 1–6 | DOI | 10.1590/1806-9282.20230314 |
| Makale Linki | chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.scielo.br/j/ramb/a/QPqsqXjBYMKLnZSzxFmmHJs/?format=pdf&lang=en | ||
| Özet |
| The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats' malondialdehyde, catalase, and superoxide dismutase levels were determined. The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001). The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models. |
| Anahtar Kelimeler |
| Cisplatin | Resveratrol | Rat | Ovary |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 3 |
| Google Scholar | 4 |