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Does resveratrol reduce cisplatin-induced ovarian damage?     
Yazarlar (8)
Barış Çıplak
Türkiye
Eyüp Gökhan Turmuş
Türkiye
Dr. Öğr. Üyesi Özlem KARA Dr. Öğr. Üyesi Özlem KARA
Türkiye
Gülçin Dağlıoğlu
Türkiye
Mehmet Murat Altındağ
Ömer Yavuz Şimşek
Türkiye
Prof. Dr. Yusuf Kenan DAĞLIOĞLU Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Mustafa KARA Prof. Dr. Mustafa KARA
Türkiye
Devamını Göster
Özet
The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats' malondialdehyde, catalase, and superoxide dismutase levels were determined. The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001). The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models.
Anahtar Kelimeler
Cisplatin | Resveratrol | Rat | Ovary
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Rev. Assoc. Med. Bras.
Dergi ISSN 0104-4230
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 08-2023
Cilt No 69
Sayı 3
Sayfalar 1 / 6
Doi Numarası 10.1590/1806-9282.20230314
Makale Linki chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.scielo.br/j/ramb/a/QPqsqXjBYMKLnZSzxFmmHJs/?format=pdf&lang=en
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 3
Google Scholar 3
Does resveratrol reduce cisplatin-induced ovarian damage?

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