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A comprehensive study on microstructure, in-vitro biodegradability, bacterial sensitivity, and cellular interactions of novel ternary Zn-Cu-xAg alloys for urological applications    
Yazarlar
Hakan Yılmazer
Yıldız Teknik Üniversitesi, Türkiye
Dr. Öğr. Üyesi Sercan BASİT Dr. Öğr. Üyesi Sercan BASİT
Türkiye
Anıl Şen
Yasemin Yılmazer
İstanbul Sabahattin Zaim Üniversitesi, Türkiye
Başak Dalbayrak
Elif Damla Arısan
Türkiye
Serdar Arısan
Türkiye
Rinat Islamgaliev
Burak Dikici
Atatürk Üniversitesi, Türkiye
Özet
Novel ternary Zn-Cu-xAg alloys are designed and fabricated by the casting method under a vacuum atmosphere and then homogenized at 350 °C for 15 h. The effect of Ag concentration (x: 0, 1, 2, 3, and 4 wt%) on microstructure, hardness, in vitro corrosion, biodegradability, and bacterial sensitivity was studied systematically. The structural analysis of the alloys was investigated by using a scanning electron microscope (SEM-EDS), and an optical microscope (OM). Besides, phase characterization of the samples was conducted using X-ray diffraction (XRD). The degradation behaviors of the alloys were determined under in vitro conditions, electrochemical polarization, and immersion tests (up to 21 days) in artificial urine (AU) solution. The maximum hardness value for Zn-1Cu-4Ag alloy was about 2.38 times higher than pure Zn due to solid-solution strengthening and precipitation hardening of (Ag, Cu)Zn4 phases. The highest and lowest Icorr values, reference also corrosion rate, were calculated in Zn-1Cu and Zn-1Cu-3Ag alloys as 17.13 and 1.318 mA·cm−2, respectively. The alloys' bacterial sensitivities were evaluated with the disc diffusion test for E. coli and S. aureus. The inhibition ratio of the Zn-1Cu-1Ag was higher than the inhibition rates of the other alloys on E. coli and S. aureus. In addition, the biological properties of the generated material were promising by altering cell survival/death ratio in both prostate epithelial and bladder cancer cells related to their use potential in urology.
Anahtar Kelimeler
Bioabsorbable | Cell culture | Degradation | In-vitro corrosion | Urological devices | Zn-Cu-Ag alloy
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of Alloys and Compounds
Dergi ISSN 0925-8388
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili Türkçe
Basım Tarihi 11-2023
Cilt No 965
Sayı 1
Doi Numarası 10.1016/j.jallcom.2023.171290
Makale Linki http://dx.doi.org/10.1016/j.jallcom.2023.171290