| Yazarlar |
Mehmet Çolak
Dicle Üniversitesi, Türkiye |
|
Kaya Gülsen
|
|
Ali Adnan Hayaloğlu
Türkiye |
Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Halil Hoşgören
Türkiye |
| Özet |
| We demonstrated that Nϵ -alkanoyl-L-lysine ethyl ester/N-alkanoyl-L-phenylalaninate gelling agents were constructed as a two-component gelling strategy and applied as drug carriers in friendly solvents commonly used. Our designs are expected to have an edge in contrast to the other lipid-based systems due to cheap raw materials, reducing the required amount of carrier, low molecular weight, ease of loading, simple dose adjustability, skin spreadability, and improved drug retention times. It could be loaded with Naproxen (Npx) with a high loading efficiency (up to 100 % as a percentage of gelator) without gel disruption. A complementary in vitro drug release study under specific pH was conducted and performed at different drug and gelator concentrations. These results reveal that the release of Npx from the supramolecular organogels was significantly retarded with increasing organogelator engagement from 0.46 % to 0.92 %, the initial release rate considerably reduced, from 18.75 % to 7.21 %, respectively; that is release rate shows a 2.6-fold decrease; this result showed that the gelator concentration could control drug release. whereas the increasing Npx concentration enhanced it. Altogether, this work produces valuable outcomes, which may be relevant to the pharmaceutical industry, suggesting that new platforms may deliver NSAID (non-steroidal anti-inflammotory drug) molecules. |
| Anahtar Kelimeler |
| Controlled drug release | low molecular weight organogelators (LMWOGs) | Rheology | Small molecule gelling agent (SMGA) | Supramolecular gels |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Chemistryselect |
| Dergi ISSN | 2365-6549 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 12-2023 |
| Cilt No | 8 |
| Doi Numarası | 10.1002/slct.202302968 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202302968 |
| Atıf Sayıları |
