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Lysine‐Based Two‐Component Organogelator: Naproxen Carrier Soft Material    
Yazarlar
Mehmet Çolak
Dicle Üniversitesi, Türkiye
Kaya Gülsen
Ali Adnan Hayaloğlu
Türkiye
Prof. Dr. Nadir DEMİREL Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Halil Hoşgören
Türkiye
Özet
We demonstrated that Nϵ -alkanoyl-L-lysine ethyl ester/N-alkanoyl-L-phenylalaninate gelling agents were constructed as a two-component gelling strategy and applied as drug carriers in friendly solvents commonly used. Our designs are expected to have an edge in contrast to the other lipid-based systems due to cheap raw materials, reducing the required amount of carrier, low molecular weight, ease of loading, simple dose adjustability, skin spreadability, and improved drug retention times. It could be loaded with Naproxen (Npx) with a high loading efficiency (up to 100 % as a percentage of gelator) without gel disruption. A complementary in vitro drug release study under specific pH was conducted and performed at different drug and gelator concentrations. These results reveal that the release of Npx from the supramolecular organogels was significantly retarded with increasing organogelator engagement from 0.46 % to 0.92 %, the initial release rate considerably reduced, from 18.75 % to 7.21 %, respectively; that is release rate shows a 2.6-fold decrease; this result showed that the gelator concentration could control drug release. whereas the increasing Npx concentration enhanced it. Altogether, this work produces valuable outcomes, which may be relevant to the pharmaceutical industry, suggesting that new platforms may deliver NSAID (non-steroidal anti-inflammotory drug) molecules.
Anahtar Kelimeler
Controlled drug release | low molecular weight organogelators (LMWOGs) | Rheology | Small molecule gelling agent (SMGA) | Supramolecular gels
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Chemistryselect
Dergi ISSN 2365-6549
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili Türkçe
Basım Tarihi 12-2023
Cilt No 8
Sayı 46
Doi Numarası 10.1002/slct.202302968
Makale Linki http://dx.doi.org/10.1002/slct.202302968
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Lysine‐Based Two‐Component Organogelator: Naproxen Carrier Soft Material

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